PMID: 3754205Feb 1, 1986Paper

Effect of respiratory acidosis on glucose homeostasis in experimental intrauterine growth retardation in rats

Early Human Development
I O FatobaW Oh

Abstract

Hypoglycemia and asphyxia account for a significant proportion of morbidity in the infant with intrauterine growth retardation (IUGR). The purpose of this study was to evaluate changes in glucose homeostasis in IUGR rats during acute respiratory acidosis. IUGR was produced by bilateral uterine artery ligation at 17 days of gestation in 14 pregnant rats with 23 successfully delivered pups. The normal pups (n = 31) were those whose mothers were sham operated at the same gestational period. The IUGR and normal pups were studied at 2 days of age. One group of pups was studied under room air while another was subjected to 20 min of exposure to a gas mixture of 10% O2/15% CO2, balanced with N2. Gluconeogenesis in the liver and carcass, as well as plasma glucose and catecholamines were determined before and after the exposure to the gas mixture. The results showed that the 2-day-old IUGR rats have lower body weight (P less than 0.001), liver weight (P less than 0.001), plasma glucose (P less than 0.001), and rate of gluconeogenesis (P less than 0.01) when compared with the normally grown rats. During respiratory acidosis, the normally grown rats showed an increase in plasma epinephrine (P less than 0.005) without significant change in...Continue Reading

References

Apr 15, 1977·The Biochemical Journal·R A IlesP G Baron
Aug 15, 1974·The New England Journal of Medicine·M W HaymondA S Pagliara
Jan 1, 1966·The Journal of Pathology and Bacteriology·W Aherne, D Hull
Dec 1, 1981·Circulation Research·D N Weismann, W R Clarke
Nov 1, 1959·The Journal of Pediatrics·M CORNBLATHE Y LEVIN
Jul 1, 1964·The Journal of Pathology and Bacteriology·J S WIGGLESWORTH

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Citations

Jul 28, 2007·Reviews in Endocrine & Metabolic Disorders·Sherin U Devaskar, Manikkavasagar Thamotharan
Feb 2, 2012·The Bulletin of Tokyo Dental College·Tatsuro Fukuyama, Masashi Yakushiji

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