PMID: 6438029Oct 1, 1984Paper

Effect of respiratory muscle weakness on P0.1 induced by partial curarization

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
R H HolleE J Pavlin

Abstract

Mouth occlusion pressure 0.1 s after onset of inspiration (P0.1) reflects central respiratory drive (CRD), but its dependence on respiratory muscle strength is unknown. To clarify this relationship, we produced progressive levels of respiratory muscle weakness by infusion of d-tubocurarine in eight supine spontaneously breathing normal subjects. Hypercapnic ventilatory response (HCVR) was measured before curarization and at mild (mean inspiratory effort 62 +/- 3% of control), moderate (42 +/- 3%), and severe (23 +/- 1%) weakness. At the severe level of weakness 1) supine functional residual capacity was not significantly changed from base line, 2) the percent of base-line slope of delta P0.1/delta PCO2 (122 +/- 27%) was significantly greater (P less than 0.01) than that for change in expired minute ventilation (delta VE)/delta PCO2 (39 +/- 10%), 3) the percent of base-line delta P0.1/delta VE (381 +/- 46%) during HCVR was significantly increased (P less than 0.01), 4) the P0.1 response was significantly increased from base line at two out of three specific levels of PCO2 while the VE was unchanged or significantly decreased, and 5) peak inspiratory resistance did not significantly change. Thus P0.1, unlike VE, did not decrease ...Continue Reading

Citations

Oct 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T J Gal
Jun 1, 1988·British Journal of Clinical Pharmacology·J J GilmartinG J Gibson
Oct 23, 2002·Journal of Applied Physiology·Chien Hui HuangPaul W Davenport
Aug 23, 2019·American Journal of Respiratory and Critical Care Medicine·Katerina VaporidiDimitris Georgopoulos
Nov 26, 2019·Current Opinion in Critical Care·Irene Telias, Savino Spadaro
Feb 26, 2020·American Journal of Respiratory and Critical Care Medicine·Irene TeliasLaurent Brochard
Sep 25, 2009·Anaesthesia and Intensive Care·J M RaurichB Togores
Mar 25, 2020·Critical Care : the Official Journal of the Critical Care Forum·Michele BertoniEwan C Goligher
Mar 25, 2020·Critical Care : the Official Journal of the Critical Care Forum·Annemijn H JonkmanLeo M A Heunks
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·M GoriniE De Paola
Oct 1, 1992·Acta Anaesthesiologica Scandinavica·L I ErikssonA Johnson
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·American Thoracic Society/European Respiratory Society
Feb 16, 2011·The International Journal of Eating Disorders·Nogah C KeremAmir Kugelman

Related Concepts

Airway Resistance
Carbon Dioxide
Functional Residual Capacity
Lung Volume Measurements
Muscle
Respiration
Tidal Volume
Tubocurarine Chloride

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