Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
J M O AndradeS H S Santos

Abstract

The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30-55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and tha...Continue Reading

References

Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Feb 3, 2005·The Journal of Biological Chemistry·Matt KaeberleinBrian K Kennedy
Mar 8, 2005·The Journal of Biological Chemistry·Margie T BorraJohn M Denu
Jul 29, 2006·Cell·Valter D Longo, Brian K Kennedy
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Jul 10, 2007·Cell Metabolism·Patrick SealeBruce M Spiegelman
Aug 23, 2008·Nature·Patrick SealeBruce M Spiegelman
Jul 31, 2009·Nature·Toren FinkelRaul Mostoslavsky
Sep 23, 2010·Current Medicinal Chemistry·S Kyrylenko, A Baniahmad
May 27, 2011·The Journal of Clinical Endocrinology and Metabolism·Paul LeeKen K Y Ho
Sep 1, 2011·Handbook of Experimental Pharmacology·Akiko SatohShin Imai
Mar 8, 2012·Nature Reviews. Molecular Cell Biology·Riekelt H HoutkooperJohan Auwerx
Jun 21, 2012·Biochimie·Koji OhashiYuji Matsuzawa
Apr 18, 2013·PloS One·Arturo Roca-RivadaMaría Pardo
Jun 26, 2013·Food Chemistry·Goiuri AlberdiMaría P Portillo
Sep 17, 2013·PloS One·Silja RaschkeJuergen Eckel
Sep 26, 2013·European Journal of Endocrinology·Maria T VamviniChristos S Mantzoros
Oct 31, 2013·Reviews in Endocrine & Metabolic Disorders·Bonggi Lee, Jianhua Shao
Mar 20, 2014·Peptides·João Marcus Oliveira AndradeSérgio Henrique Sousa Santos
Jul 16, 2014·Peptides·Sérgio Henrique Sousa Santos, João Marcus Oliveira Andrade
Aug 12, 2014·BioMed Research International·Ersilia NigroAurora Daniele
Sep 13, 2015·Neurology·R Scott TurnerUNKNOWN Alzheimer's Disease Cooperative Study
Jan 15, 2017·Journal of Neuroinflammation·Charbel MoussaR Scott Turner
May 10, 2017·International Journal of Molecular Sciences·Mark K NøhrSteen B Pedersen

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Citations

Feb 13, 2020·Food & Nutrition Research·Zihui LiuXiang Feng
Sep 3, 2020·International Journal of Molecular Sciences·Alina Kuryłowicz, Monika Puzianowska-Kuźnicka
Dec 19, 2020·IBRO Reports·Daniel Silva MoraesSérgio Henrique Sousa Santos
Mar 31, 2021·Pharmaceutical Research·Youngshim Choi, Liqing Yu
Aug 8, 2021·International Journal of Molecular Sciences·Pamela SenesiIleana Terruzzi
Jul 8, 2020·Journal of Agricultural and Food Chemistry·Zeynep GoktasShu Wang
Aug 31, 2021·Journal of Agricultural and Food Chemistry·Yen-Chun KohMin-Hsiung Pan
Nov 6, 2021·Critical Reviews in Food Science and Nutrition·Zhenyu WangZhiyong He

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