Effect of retinoic acid on the acylation of phospholipids in granulocytes in vitro

Biochemical and Biophysical Research Communications
J Tou

Abstract

The influence of retinoic acid on the incorporation of [1-14C]palmitic acid and [1-14C]arachidonic acid into phospholipids was examined in guinea pig peritoneal granulocytes. All-trans-retinoic acid inhibited the incorporation of both fatty acids into phosphatidic acid and phosphatidylinositol. However, it stimulated the incorporation of both fatty acids into phosphatidylcholine but not other phospholipids. All-trans-retinoic acid was more effective than 13-cis-retinoic acid. The influence of all-trans-retinoic acid on the acylation of phospholipids was concentration-dependent with significant effect occurring at 2.1 microM. The loss of labeled fatty acids from prelabeled phospholipids and the transport of labeled fatty acids into granulocytes were not responsive to the presence of retinoic acid in the incubation media. These results suggest that retinoic acid may affect the activities of acyltransferases involved in the synthesis of phosphatidic acid, phosphatidylinositol and phosphatidylcholine.

References

May 5, 1975·Biochimica Et Biophysica Acta·K J Tou, R L Stjernholm
Sep 7, 1972·Biochimica Et Biophysica Acta·L R RohrschneiderR K Boutwell
Feb 15, 1980·International Journal of Cancer. Journal International Du Cancer·J Abb, F Deinhardt
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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