Effect of retinoic acid on two glycosyltransferase activities in C6 cultured glioma cells

The International Journal of Biochemistry
P ReboulP Louisot

Abstract

1. Activity of two glycosyltransferases was studied in retinoic acid-treated C6 cultured glioma cells. 2. The beta-galactoside alpha 2,3-sialyltransferase transferring N-acetylneuramin onto the O-glycans residues of glycoproteins was activated up to twice after chronic treatment (from 24 to 96 hr) with all-trans retinoic acid. 3. No effect was observed for shorter treatments. 4. On the opposite, the N-glycan galactosyltransferase activity remained unchanged whatever the length of retinoic acid treatment was. 5. The activatory effect was not dependent on isomery, as all-trans and 13-cis retinoic acid isomers were both activators of the C6 glioma cell sialyltransferase. 6. Measurement of adhesion of retinoic acid-treated cells using labelled plasma membranes showed an enhancement of adhesion in correlation with enhancement of sialyltransferase activity.

References

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Citations

Feb 1, 1994·Molecular and Chemical Neuropathology·D L VanderMeulenJ R Moskal
Jan 1, 1991·The International Journal of Biochemistry·P BroquetP Louisot
Oct 1, 1993·Journal of Pediatric Surgery·K W ReichardH M Reyes
Oct 17, 2009·Expert Review of Neurotherapeutics·Joseph R MoskalGlyn Dawson

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