Effect of retinol palmitate eye drops on experimental keratoconjunctival epithelial damage induced by n-heptanol in rabbit

Current Eye Research
Hiroshi ToshidaAkira Murakami

Abstract

To investigate ability of vitamin A (VA, retinol palmitate) to promote wound healing after injury in rabbit eye. After keratoconjunctival injury by 20 microL of n-heptanol, VA eye drops at 500, 1000, or 1500 IU/mL were started 6 times a day for 11 days. Fluorescein and rose bengal staining and histological analysis were performed. Fluorescein staining was significantly reduced by 1000 and 1500 IU/mL of VA and rose bengal staining by all concentrations. Histological examination revealed acceleration of wound healing after 7 days (1500 IU/mL). VA may be useful in treatment of keratoconjunctival injury.

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Citations

Oct 12, 2012·Clinical Ophthalmology·Akito OdakaAkira Murakami
Dec 24, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Nobuhito TabuchiAkira Murakami
Sep 7, 2016·Scientific Reports·Aurélie ComptourVincent Sapin
Nov 4, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Masako HattoriTsunehiko Ikeda
Sep 29, 2020·Clinical Ophthalmology·Mohammad Soleimani, Morteza Naderan

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