Effect of Retro-Inverso Isomer of Bradykinin on Size-Dependent Penetration of Blood-Brain Tumor Barrier

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Bingxia SuMin Liu

Abstract

Retro-inverso bradykinin (RI-BK) has better metabolic stability and higher affinity for the BK type 2 (B2) receptor, compared with bradykinin. At low doses, RI-BK can selectively enhance the permeability of the blood-brain tumor barrier (BBTB) without harming normal brain tissue. In this study, gold nanoparticles (GNPs) of size ranging from 5 to 90 nm are synthesized to assess the optimal size of nanocarriers that achieves maximum brain accumulation after the treatment of RI-BK. The ability of the GNPs to cross the BBTB is tested in a rat C6 glioma tumor model. The results of inductively coupled plasma-mass spectrometry and transmission electron microscopy indicate that GNPs with size of 70 nm achieve maximum permeability to the glioma. The present study supports the conclusion that RI-BK can enhance the permeability of BBTB and provides fundamental information for further development of nanomedicines or nanoprobes for glioma therapy.

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Citations

Dec 26, 2018·Chemical Biology & Drug Design·Jagdish Rai
Nov 18, 2020·Pharmaceutics·Huilong Luo, Eric V Shusta
Jul 14, 2021·Nature Reviews. Clinical Oncology·Patricia S Steeg
Aug 11, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Enoch AppiahMamoru Haratake
Aug 14, 2019·Bioconjugate Chemistry·Yanyan HuaiPriyabrata Mukherjee

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