Effect of Rho-kinase inhibition on complexity of breathing pattern in a guinea pig model of asthma

PloS One
Saeed PazhoohanSohrab Hajizadeh

Abstract

Asthma represents an episodic and fluctuating behavior characterized with decreased complexity of respiratory dynamics. Several evidence indicate that asthma severity or control is associated with alteration in variability of lung function. The pathophysiological basis of alteration in complexity of breathing pattern in asthma has remained poorly understood. Regarding the point that Rho-kinase is involved in pathophysiology of asthma, in present study we investigated the effect of Rho-kinase inhibition on complexity of respiratory dynamics in a guinea pig model of asthma. Male Dunkin Hartley guinea pigs were exposed to 12 series of inhalations with ovalbumin or saline. Animals were treated by the Rho-kinase inhibitor Y-27632 (1mM aerosols) prior to each allergen challenge. We recorded respiration of conscious animals using whole-body plethysmography. Exposure to ovalbumin induced lung inflammation, airway hyperresponsiveness and remodeling including goblet cell hyperplasia, increase in the thickness of airways smooth muscles and subepithelial collagen deposition. Complexity analysis of respiratory dynamics revealed a dramatic decrease in irregularity of respiratory rhythm representing less complexity in asthmatic guinea pigs. I...Continue Reading

References

Jun 8, 1978·The New England Journal of Medicine·M CosioP T Macklem
Feb 1, 1992·Allergy·J BousquetF B Michel
Nov 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S YingQ Hamid
Nov 1, 1994·Journal of Applied Physiology·M Sammon
Apr 1, 1994·The American Journal of Physiology·S M Pincus, A L Goldberger
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·I F TibérioM A Martins
Jun 8, 1999·Annual Review of Immunology·M Wills-Karp
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J S Richman, J R Moorman
Sep 1, 2000·Respiration Physiology·G Benchetrit
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·M Wills-Karp
Aug 18, 2001·Journal of Applied Physiology·C L QueG N Maksym
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·C Y ChenJ P Joad
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Joost G Van den Aardweg, John M Karemaker
Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Wei DuanW S Fred Wong
May 4, 2005·The Journal of Allergy and Clinical Immunology·Makoto YoshidaPaul M O'Byrne
Jan 18, 2006·Journal of Applied Physiology·Tatiana LançasMarisa Dolhnikoff
Apr 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F TakiK Shimokata
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Jan 15, 2008·Biochemical and Biophysical Research Communications·Haruka AokiMasatomo Mori
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dedmer SchaafsmaHerman Meurs
Nov 18, 2008·Respiratory Physiology & Neurobiology·Ziyad SamaraChristian Straus
Dec 17, 2008·Journal of Applied Physiology·Cindy Thamrin, Urs Frey
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renat ShaykhievRonald G Crystal
Feb 5, 2011·Journal of Applied Physiology·Urs FreyBéla Suki
May 14, 2011·The European Respiratory Journal·M ZhuJ K Liao
May 14, 2011·Journal of Applied Physiology·Juliana VeigaPedro L Melo
Feb 24, 2012·Journal of Cellular and Molecular Medicine·Heela SarlusMircea Oprica
Jun 19, 2012·American Journal of Respiratory and Critical Care Medicine·Carlo GulottaRaffaele L Dellacà
Sep 25, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Samantha Souza PossaIolanda de Fátima Lopes Calvo Tibério
Sep 17, 2013·PloS One·Amir H ShiraziAli R Mani
Jan 1, 2014·Respiratory Physiology & Neurobiology·Renato Fraga RighettiIolanda de Fátima Lopes Calvo Tibério
Oct 12, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bo LanChun Y Seow
Oct 18, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·David I KasaharaStephanie A Shore
Jan 30, 2016·PloS One·Mohammad Reza RaoufySohrab Hajizadeh
Nov 1, 2016·American Journal of Respiratory and Critical Care Medicine·Cindy ThamrinPeter J Sterk

❮ Previous
Next ❯

Citations

Jun 6, 2020·Clinical Science·Mikael AdnerSven-Erik Dahlén
Apr 17, 2021·ACS Pharmacology & Translational Science·Thomas W FlanaganCharles D Nichols
Jan 24, 2022·Respiratory Physiology & Neurobiology·Atefeh SadeghiMorteza Valizadeh

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
fluorescence microscopy
PCR
bronchoalveolar lavage

Software Mentioned

GraphPad Prism
ChartPro
GraphPad
MATLAB

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Respiratory Physiology & Neurobiology
Mehdi Eslami-BehrooziMohammad Reza Raoufy
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Xiao-yan ZhaoRu-lian Bian
Allergology International : Official Journal of the Japanese Society of Allergology
Kohei Yamauchi, Hiroshi Inoue
© 2022 Meta ULC. All rights reserved