PMID: 11913333Mar 27, 2002Paper

Effect of risperidone on serum cytokines

The International Journal of Neuroscience
D J KimY K Kim

Abstract

A variety of cytokines are dysregulated in schizophrenia, and some antipsychotic drugs effect cytokines. In order to examine the effect of risperidone on plasma cytokines, we measured the serum level of IL-1b, IL-2, IL-6, IL-12, and INF-g during acute states of illness, and after 4 weeks of treatment with risperidone in 19 schizophrenic patients. The patients' psychopathology was assessed by PANSS. Plasma IL-12 levels increased significantly after 4 weeks of treatment (p = .002). Plasma IL-b, IL-2, IL-6, and INF-g levels were not significantly different before and after treatment. There were no significant correlations between the changes in cytokine levels and the changes in PANSS scores. Increased IL-12 may contribute to activation of immune responses during treatment with risperidone. IL-12 may play an important role in immune responses related to neuropsychiatry.

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Citations

Sep 8, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Feng-Shiun ShieIng-Kang Ho
Sep 18, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark H Rapaport, Catherine Bresee
Jan 23, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Minli DingLuxian Lv
Nov 10, 2013·Schizophrenia Research·Valérie TourjmanStéphane Potvin
Jul 15, 2009·International Immunopharmacology·Seetharamaiah ChittiprolBangalore N Gangadhar
Feb 5, 2008·Psychiatry Research·Benedicto Crespo-FacorroJosé Luis Vázquez-Barquero
Apr 14, 2016·BioMed Research International·Chang-Chieh WuChun-Hua Wang
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Apr 4, 2006·Brain, Behavior, and Immunity·Lukasz DrzyzgaZbigniew S Herman
Dec 3, 2014·International Immunopharmacology·Mao-Liang ChenFu-Ming Tsai
Jun 2, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Raouf IgueEdouard Kouassi
Aug 29, 2013·Immunopharmacology and Immunotoxicology·Mao-Liang ChenFu-Ming Tsai
Mar 1, 2006·International Immunopharmacology·Chi-Un PaeIn-Ho Paik
Feb 12, 2013·Brain, Behavior, and Immunity·Melissa L SinkusSherry Leonard
Oct 27, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrea SchmittUNKNOWN Members of the WFSBP Task Force on Biological Markers
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David L GarverJennifer A Holcomb
Jan 8, 2018·Molecular Neurobiology·Dominika GładyszKamil K Hozyasz
Jul 18, 2018·The International Journal of Neuropsychopharmacology·Bruno RomeoAmine Benyamina
Nov 20, 2018·Journal of Leukocyte Biology·Corneliu SimaMichael Glogauer
Nov 27, 2007·Neuropsychobiology·Kyeong-Sae Na, Yong-Ku Kim

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