Abstract
New target-specific oral anticoagulants may have benefits, such as shorter hospital length of stay, compared to warfarin in patients with nonvalvular atrial fibrillation (NVAF). This study aimed to assess, among patients with NVAF, the effect of rivaroxaban versus warfarin on health care costs in a cohort of rivaroxaban users and matched warfarin users. Health care claims from the Humana database from 5/2011 to 12/2012 were analyzed. Adult patients newly initiated on rivaroxaban or warfarin with ≥2 atrial fibrillation (AF) diagnoses (The International Classification of Diseases, Ninth Revision, Clinical Modification: 427.31) and without valvular AF were identified. Based on propensity score methods, warfarin patients were matched 1:1 to rivaroxaban patients. Patients were observed up to end of data, end of insurance coverage, death, a switch to another anticoagulant, or treatment nonpersistence. Health care costs [hospitalization, emergency room (ER), outpatient, and pharmacy costs] were evaluated using Lin's method. Matches were found for all rivaroxaban patients, and characteristics of the matched groups (n = 2253 per group) were well balanced. Estimated mean all-cause and AF-related hospitalization costs were significantly l...Continue Reading
References
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Apr 12, 2001·Journal of Clinical Epidemiology·S T NormandB J McNeil
Jul 30, 2003·Circulation·Wendy A WattigneyJanet B Croft
Oct 22, 2005·Current Medical Research and Opinion·Eric Q WuJeremy Ruskin
Jul 24, 2008·Chest·Jack AnsellGualtiero Palareti
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
May 5, 2011·Circulation. Cardiovascular Quality and Outcomes·Michael H KimKathy L Schulman
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Feb 15, 2012·Chest·Walter AgenoGualtiero Palareti
Jun 2, 2012·The American Journal of Cardiology·Soyon LeeCraig I Coleman
Sep 21, 2012·Neurology·Hooman KamelAnthony S Kim
Dec 6, 2012·Clinical Pharmacology and Therapeutics·S ManthaJ Ansell
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 10, 2013·Journal of Postgraduate Medicine·S Aditya
Apr 4, 2013·Stroke; a Journal of Cerebral Circulation·Amanda R HarringtonDaniel C Malone
Apr 30, 2013·PloS One·Brendan L LimoneCraig I Coleman
Jun 14, 2013·Current Atherosclerosis Reports·Graeme J Hankey, John W Eikelboom
Sep 14, 2013·PharmacoEconomics·Joris KleintjensMimi De Ruyck
Sep 26, 2013·Current Medical Research and Opinion·Hye Duck Choi, Wan Gyoon Shin
Oct 19, 2013·Clinical Drug Investigation·Carla RognoniNicola Lucio Liberato
Dec 3, 2013·Pain Practice : the Official Journal of World Institute of Pain·Robert DufourNick C Patel
May 17, 2014·Advances in Therapy·Wenhui WeiJasvinder Gill
May 21, 2014·Circulation·Nileshkumar J PatelHakan Paydak
Oct 17, 2014·Cardiovascular Drugs and Therapy·Ye WangYu Ko
Citations
Sep 24, 2015·Current Medical Research and Opinion·Colleen A McHorneySteven Deitelzweig
Dec 18, 2015·Journal of the American Association of Nurse Practitioners·Barbara A Bentz
Mar 31, 2016·Journal of Medical Economics·Lin XieJeffrey Trocio
Nov 30, 2016·Journal of Thrombosis and Thrombolysis·Andreas Zirlik, Christoph Bode
Jun 22, 2017·Current Medical Research and Opinion·Alpesh AminLien Vo
Jul 1, 2017·Current Medical Research and Opinion·Christine G KohnCraig I Coleman
Apr 26, 2018·Journal of Managed Care & Specialty Pharmacy·Chinmay G DeshpandeCynthia Willey
Apr 26, 2018·Journal of Managed Care & Specialty Pharmacy·Shoroq M AltawalbehJoshua M Thorpe
Sep 18, 2015·Therapeutic Advances in Cardiovascular Disease·Delilah McCarty, April Robinson
Nov 24, 2017·Current Medical Research and Opinion·Adrienne M GilliganStephen Sander
Feb 6, 2019·International Journal of Clinical Pharmacy·Tomohide AkaseMasami Morita
Nov 22, 2018·American Journal of Therapeutics·Wilbert S Aronow, Tatyana A Shamliyan
Sep 25, 2019·Journal of Medical Economics·Ritam ChowdhuryBriain O Hartaigh
Sep 9, 2020·Journal of Medical Economics·Dejan MilentijevicPatrick Lefebvre
Jan 31, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Manasi DatarGeorge A Andrews
Jan 28, 2021·Journal of Medical Economics·Dejan MilentijevicMark Alberts
Apr 14, 2019·American Heart Journal·Eric D PetersonAlex C Spyropoulos
Apr 30, 2021·Journal of Medical Economics·Jeffrey S BergerVeronica Ashton
Oct 27, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Matthew R WeirVeronica Ashton