PMID: 9444638Jan 28, 1998Paper

Effect of romifidine and romifidine-butorphanol for sedation in dogs

The Journal of Small Animal Practice
G C England, N Watts

Abstract

The sedative and physiological effects of intravenous romifidine at 120 micrograms/kg were compared with intravenous romifidine (120 micrograms/kg) followed immediately by intravenous butorphanol (0.1 mg/kg) in 18 clinically normal adult beagles in a blinded randomised change-over study. Following the injection of romifidine alone the dogs became recumbent and there was an increase in a subjective score awarded to the degree of sedation. Heart rate and respiratory rate decreased and minor bradyarrhythmias were noted. The romifidine-butorphanol combination produced a significant decrease in the time to the onset of sedation and increase in the sedative effect and duration of action compared with romifidine alone. With the exception of a further decrease in heart rate and respiratory rate, there were no additional side effects following the use of the romifidine-butorphanol combination. The marked sedative effect associated with this combination would appear to be useful in the clinical situation where an increased degree of sedation is required.

References

Apr 6, 1991·The Veterinary Record·N Jarvis, G C England
Jan 1, 1996·The Journal of Small Animal Practice·G C EnglandR Hammond
Feb 1, 1996·The Journal of Small Animal Practice·G C EnglandR A Hammond

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Citations

Dec 22, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A K SharmaA Shahi
Jul 30, 2011·The Journal of Small Animal Practice·E Vettorato, S Bacco
Apr 16, 2011·Veterinary Anaesthesia and Analgesia·Rocío NavarreteRafael J Gómez-Villamandos
Jul 23, 2004·Veterinary Anaesthesia and Analgesia·André L SelmiBruno T Lins
Aug 20, 2002·Journal of the American Veterinary Medical Association·André L SelmiConcepta McManus
Dec 17, 2008·The Veterinary Record·I NussbaumerC Peterbauer
Jan 1, 2002·Veterinary Anaesthesia and Analgesia·Melissa D SinclairGlenn Pettifer

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