Effect of root canal debridement on inflammatory cytokine levels

Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc
Jue Ann SohFabian Davamani Amalraj

Abstract

In endodontic infections, inflammatory mediators such as cytokines are released, recruited and retained until the infection is eradicated. Root canal therapy is performed to prevent the spread of infection. The aim of this study was to investigate the effects of root canal debridement (cleaning and shaping) on periapical inflammation by measuring the levels of inflammatory cytokines, Interleukin-8 (IL-8) and Interleukin-10 (IL-10). The study includes twenty patients with pulp necrosis and asymptomatic apical periodontitis. Periradicular sample was collected using paper points before and after root canal debridement. Cytokine levels were determined by Sandwich Enzyme-Linked Immunosorbent Assay (ELISA). Data were analysed using paired t-test (PASW Statistics 18) (P = 0.05). All samples showed the presence of IL-8 and IL-10 prior to root canal debridement. Significantly reduced levels (P < 0.05) of IL-8 and IL-10 were detected after root canal debridement. In conclusion, root canal debridement significantly decreased the levels of the tested pro- and anti-inflammatory cytokine in the periradicular interstitial fluid.

References

Jun 1, 1990·Endodontics & Dental Traumatology·P Stashenko
Nov 1, 1987·Journal of Endodontics·S M Yu, P Stashenko
Jun 26, 2003·International Endodontic Journal·Jose F Siqueira
Dec 3, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P N R Nair
Sep 7, 2006·Journal of Periodontal Research·Konrad TietzeClaudia Nonnenmacher
Sep 20, 2007·Journal of Endodontics·Zulema Rosalia Arias MartinezShogo Takashiba
Dec 18, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yoshiki HamadaKanichi Seto
May 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Dragan GazivodaMiodrag Colic
Jun 13, 2009·Oral Diseases·N RoescherG G Illei
Nov 26, 2009·Journal of Applied Oral Science : Revista FOB·Alessandra Cecília Oliveira SilvaBruno Neves Cavalcanti
Jan 28, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tatiana Beber Teixeira-SalumAdriano Motta Loyola
Feb 18, 2010·International Endodontic Journal·Y-L NgK Gulabivala
Apr 23, 2010·Annals of the Rheumatic Diseases·Nienke RoescherGabor G Illei
Jan 11, 2011·Journal of Conservative Dentistry : JCD·L Lakshmi Narayanan, C Vaishnavi
May 7, 2011·Journal of Oral Microbiology·Dana T GravesGustavo P Garlet
Jul 19, 2011·Journal of Endodontics·Aldo E Del Carpio-PerochenaRonald Ordinola-Zapata
Nov 22, 2011·Journal of Endodontics·Luiz Carlos Feitosa HenriquesAntônio Paulino Ribeiro Sobrinho
Mar 15, 2012·Journal of Endodontics·Luciana Carla Neves de BritoAntônio Paulino Ribeiro Sobrinho
Oct 16, 2012·Journal of Pharmacy & Bioallied Sciences·Harikaran JayakodiSabeena Mathew
Dec 18, 2012·International Endodontic Journal·M ElsalhyR Raghupathy
Apr 24, 2014·Advances in Wound Care·Alice KingSundeep G Keswani
Mar 10, 2016·Journal of Endodontics·Augusto C Sette-DiasPaula P Magalhães
Dec 4, 2016·Dental Clinics of North America·Ashraf F Fouad

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