Effect of Roughness on in Situ Biomineralized CaP-Collagen Coating on the Osteogenesis of Mesenchymal Stem Cells

Langmuir : the ACS Journal of Surfaces and Colloids
Xingjie ZanQian Wang

Abstract

Because of its outstanding osteo-conductive property, a calcium phosphate (CaP) coating has been used as an implant coating for bone tissue engineering. Nevertheless, the issues, such as harsh fabrication conditions, long-term stability and biocompatibility, and the requirement for expensive instruments, still exist in current coating techniques. To address these issues, the CaP coatings doped with collagen (CaP-Col) were in situ generated on polyelectrolyte multilayers (PEMs) by incubating PEMs in a mixture of the collagen, phosphate, and calcium ions. The resulting coatings have controllable physical properties (chemical composition, crystallinity, and roughness) and good stability before and after incubation with cell culture medium. We also found that both the cellular viability and osteogenesis of mesenchymal stem cells (MSCs) were closely related to the roughness of PEMs/CaP-Col, one of the easily ignored physical factors in current coating designs but very critical. The existed roughness window (between 18 ± 1.2 and 187 ± 7.3 nm) suitable for MSC proliferation on PEMs/CaP-Col coating and the optimal roughness (∼98 ± 3.5 nm) for MSC osteogenesis further demonstrated that the roughness was a critical factor for bone format...Continue Reading

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Citations

Jul 5, 2016·Frontiers in Bioengineering and Biotechnology·Silvia PanseriMonica Sandri
Aug 19, 2016·ACS Applied Materials & Interfaces·Gráinne M CunniffeFergal J O'Brien
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Oct 6, 2018·Journal of Biomedical Materials Research. Part a·Xing YangQingling Feng
Jul 19, 2020·Biomimetics·Muhammad Sohail ZafarNaresh Kumar
Oct 31, 2020·Journal of Biomedical Materials Research. Part a·Daniella MarxMark Towler
Oct 19, 2020·Journal of Biomedical Materials Research. Part a·Claudia P MarinEdgar D Zanotto
Apr 30, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Meng LiYifu Guan

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