Effect of route on inoculation on host resistance to Nocardia.

Infection and Immunity
B L BeamanJ Rosen

Abstract

Virulent strains of Nocardia asteroides and Nocardia caviae were injected into mice by five different routes. When these organisms were grown to the same stage of growth in the same medium and otherwise prepared identically, it was found that they differed significantly in their ability to infect and kill the host, depending entirely upon the route of inoculation. Thus, N. caviae 112 was 30 times more virulent than N. asteroides GUH-2 when administered intranasally, whereas N. asteroides was at least 10 times more pathogenic than N. caviae when injected intravenously. They had similar degrees of virulence when given intraperitoneally. N. asteroides GUH-2 induced a more persistent and progressive infection than N. caviae 112 when injected into the footpads of mice; however, the latter strain was more lethal for the animals when given by this route. Different routes of infecting mice indicate a compartmentalization of the host response to different strains of nocardia. Therefore, the use of different strains of nocardia under carefully controlled and defined conditions should make it possible to dissect the nocardia-host interactions at the cellular levels.

References

Jun 1, 1977·Infection and Immunity·B L Beaman, S Maslan
Apr 1, 1978·Infection and Immunity·B L Beaman, S Maslan
Sep 13, 1979·The New England Journal of Medicine·W G Hocking, D W Golde
May 1, 1976·Infection and Immunity·P I FolbG Altmann
Jun 1, 1975·The Journal of Infectious Diseases·J A Krick, J S Remington
Feb 1, 1973·Infection and Immunity·S K MishraS Abraham
Aug 1, 1973·Canadian Journal of Microbiology·A Gonzalez Ochoa
Jan 1, 1971·Journal of Comparative Pathology·I M Smith, A H Hayward
Jan 1, 1970·Mycopathologia et mycologia applicata·P V KurupS Abraham

❮ Previous
Next ❯

Citations

Dec 1, 1983·The Journal of Hygiene·R J Hay
Mar 6, 2009·Veterinary Pathology·J A St LegerK A Terio
Dec 1, 1983·The Journal of Hygiene·B L Beaman, A M Sugar
Jan 1, 1994·Biotherapy·B J Kullberg, J W van 't Wout
Feb 1, 1986·Mycopathologia·R A Fromtling, H J Shadomy
Nov 1, 1986·Mycopathologia·H C GugnaniS E Ikerionwu
Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N Khardori
Mar 9, 2007·Annals of the New York Academy of Sciences·Karl V ClemonsDavid A Stevens
Apr 1, 1994·Clinical Microbiology Reviews·B L Beaman, L Beaman
Aug 1, 1980·Infection and Immunity·B L BeamanY Ohsugi
Jan 1, 1982·Infection and Immunity·B L BeamanR Deem
Apr 12, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Fred A LopezMark Holodniy
Nov 1, 1987·Journal of Clinical Microbiology·J C AdairJ M Johnston
May 1, 1992·Infection and Immunity·S A Ogata, B L Beaman
Dec 1, 1982·Infection and Immunity·R L DeemM E Gershwin
Dec 1, 1982·Infection and Immunity·C CondeL Ortiz-Ortiz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.