Effect of RTKN on progression and metastasis of colon cancer in vitro

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Guo-Qiang QuWu-Ming Kong

Abstract

Like many epithelial-derived cancers, colon cancer results from a multistep tumorigenic process. However, the detailed mechanisms involved in colon cancer formations are poorly characterized. In the present study, we investigated the role of RTKN in colon cancer and explored underlying mechanisms. The results showed that RTKN expression was significantly increased in colon cancer tissues when compared with the adjacent tissues of patients in Shanghai People's hospital and in TCGA independent dataset. Furthermore, silencing of RTKN inhibited cell proliferation, migration, invasion, and arrested cell cycle at G1 phase in LOVO cells. Bioinformatics analysis demonstrated that DNA replication and cell cycle were involved in the regulation of RTKN. MCM2/3/5, CDK1/2 and PCNA expression had a direct relationship with the reduction of RTKN. RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2/3/5, CDK1/2 and PCNA, suggesting that RTKN was a potential target for treating colon cancer.

References

Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
May 1, 1997·The Journal of Clinical Investigation·H ShengR N DuBois
May 19, 2000·The Biochemical Journal·A L Bishop, A Hall
Nov 4, 2000·Cell Proliferation·M Molinari
Nov 7, 2000·Current Opinion in Cell Biology·H TakisawaY Kubota
May 7, 2002·Nature Cell Biology·Erik Sahai, Christopher J Marshall
Feb 25, 2009·Nature Reviews. Cancer·Marcos Malumbres, Mariano Barbacid
Apr 11, 2009·International Journal of Oncology·Shihua WangRobert Chunhua Zhao
May 6, 2009·Stem Cells·Shigeo TakaishiTimothy C Wang
May 20, 2009·The Journal of Clinical Investigation·Jacqueline E PaytonTimothy J Ley
Jun 30, 2010·Prostate Cancer and Prostatic Diseases·S SevliM Ozen

❮ Previous
Next ❯

Citations

Aug 9, 2016·Biochemical and Biophysical Research Communications·Bin LiHuifang Guo
Nov 12, 2016·BMC Genomics·James DenvirJung Han Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.