Effect of ruthenium red on responses mediated by activation of capsaicin-sensitive nerves of the rat urinary bladder.

Naunyn-Schmiedeberg's Archives of Pharmacology
C A MaggiA Meli

Abstract

(1) Topical administration of Ruthenium Red (10-100 microM in saline) to the serosal surface of the urinary bladder in urethane-anesthetized rats prevented the motor response of the urinary bladder to topical administration of capsaicin and protected the sensory fibers from capsaicin desensitization, but had no effect on the volume-evoked contractions (micturition reflex). At 1 mM increased bladder capacity and decreased amplitude of micturition contraction were observed. (2) At 100 microM, topical Ruthenium Red prevented the blood pressure rise produced by topical administration of capsaicin onto the bladder but did not affect the blood pressure rise produced by sudden bladder distension in spinal rats. (3) After intrathecal administration, Ruthenium Red (80-800 ng/rat) produced a long lasting inhibition of the micturition reflex in urethane-anesthetized rats, this effect being evident in both vehicle- or capsaicin- (50 mg/kg s.c. 4 days before) pretreated rats. At 800 ng/rat, intrathecal Ruthenium Red did not affect the blood pressure rise produced by topical administration of capsaicin onto the rat bladder nor that produced by bladder distension. (4) These findings provide further evidence that Ruthenium Red acts quite selec...Continue Reading

Citations

Sep 21, 1990·European Journal of Pharmacology·R AmannF Lembeck
Sep 4, 1990·European Journal of Pharmacology·M TakakiS Nakayama
Jan 1, 1996·Respiration Physiology·A M NaidaO P Mathew
Apr 1, 1991·Journal of the Autonomic Nervous System·C A Maggi
Oct 1, 1992·British Journal of Pharmacology·S BevanJ C Yeats

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