PMID: 30014639Jul 18, 2018Paper

Effect of Rutin on Liver Function and Morphology in Type 1 Diabetes Mice Induced by Streptozotocin

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Cong-Wei LiJing Bai

Abstract

To investigate the effect of Rutin on the function and morphology of liver in type 1 diabetes mice induced by streptozotocin (STZ). Type 1 diabetic mice model was established with the treatment of STZ by a 5 d intraperitoneal administration to male Kunming mice. Normal group had 12 mice without treatment of STZ,the mice with DM after STZ treated were randomly divided into DM group,low-dose (50 mg/kg) Rutin group and high-dose (100 mg/kg) Rutin group,each group had 12 mice. The mice in normal and DM group were given sodium carboxymethyl cellulose (10 mg/kg). Each mice was given above drugs by intragastric administration for 8 weeks. Postprandial random blood glucose was measured at 4 weeks and 8 weeks and the levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),lactate dehydrogenase (LDH),total protein (TP) and albumin (ALB) in serum were detected by automatic biochemical analyzer after 8 weeks. The morphology of liver was observed by HE and Masson staining. The ultrastructure of liver tissue was observed by electron microscope. After a continuous small-dose injection of STZ,the success rate of diabetes model mice were up to 98%. The blood glucose of the model group was significantly increased (P<0.01),and t...Continue Reading

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Hao-Xuan CaoJing Bai
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Ming YangDe-wei Yu
The Journal of Veterinary Medical Science
Atchariya PomjunyaWirasak Fungfuang
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Tian-Jiao GaoXian-Mei Li
© 2022 Meta ULC. All rights reserved