Effect of Saccharomyces cerevisiae strain UFMG A-905 in experimental model of inflammatory bowel disease

Beneficial Microbes
F C P TiagoJ R Nicoli

Abstract

In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used: not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-905 (905); treated with the non-probiotic S. cerevisiae W303 (W303); challenged with DSS (DSS); treated with S. cerevisiae UFMG A-905 and challenged with DSS (905 + DSS); and treated with S. cerevisiae W303 and challenged with DSS (W303 + DSS). Seven days after induction of UC, mice were euthanised to remove colon for enzymatic, immunological, and histopathological analysis. In vivo intestinal permeability was also evaluated. An improvement of clinical manifestations of experimental UC was observed only in mice of the 905 + DSS group when compared to animals from DSS and W303 + DSS groups. This observation was confirmed by histological and morphometrical data and determination of myeloperoxidase and eosinophil peroxidase activities, intestinal permeability and some pro-inflammatory cytokines. S. cerevisiae UFMG A-905 showed to be a potential alternative treatment for UC when used in an experimental animal model of t...Continue Reading

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Citations

Mar 24, 2016·Digestive Diseases and Sciences·Flaviano S Martins
Aug 26, 2016·Critical Reviews in Microbiology·Amir SaberAhmad Yari Khosroushahi
Feb 7, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Vanessa M B FonsecaMarcos de C Borges
Aug 24, 2017·FEMS Microbiology Reviews·Rebeca MartínPhilippe Langella
Jan 19, 2019·Applied Microbiology and Biotechnology·Miriam AnguloCarlos Angulo
Mar 25, 2017·Scientific Reports·Indu KhatriSrikrishna Subramanian
Jan 11, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S ShamekhiN Zarghami
Mar 25, 2021·Probiotics and Antimicrobial Proteins·Joana O P A CoutinhoFlaviano S Martins
Jun 30, 2021·Nature Medicine·Benjamin M ScottFrancisco J Quintana
Jul 17, 2021·Frontiers in Cellular and Infection Microbiology·Su-Bin HwangDeog-Hwan Oh
Jul 14, 2021·Probiotics and Antimicrobial Proteins·Joana O P A CoutinhoFlaviano S Martins

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