Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial.

Psychopharmacology
Amirhossein ModabberniaS Akhondzadeh

Abstract

Saffron (Crocus sativus L.) has shown aphrodisiac effects in some animal and human studies. To assess the efficacy and tolerability of saffron in fluoxetine-related sexual dysfunction. This was a 4-week randomized double-blind placebo-controlled study. Thirty-six married male patients with major depressive disorder whose depressive symptoms had been stabilized on fluoxetine and had subjective complaints of sexual impairment entered the study. The patients were randomly assigned to saffron (15 mg twice per day) or placebo for 4 weeks. International Index of Erectile Function scale was used to assess sexual function at baseline and weeks 2 and 4. Thirty patients finished the study. Baseline characteristics as well as baseline and final depressive symptoms scores were similar between the two groups. Effect of time × treatment interaction on the total score was significant [Greenhouse-Geisser-corrected, F (1.444, 40.434) = 6.154, P = 0.009]. By week 4, saffron resulted in significantly greater improvement in erectile function (P < 0.001) and intercourse satisfaction domains (P = 0.001), and total scores (P < 0.001) than the placebo group. Effect of saffron did not differ significantly from that of placebo in orgasmic function (P = ...Continue Reading

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Feb 23, 2013·Depression Research and Treatment·David S BaldwinVasilios G Masdrakis
Mar 30, 2013·The Psychiatric Clinics of North America·Amirhossein Modabbernia, Shahin Akhondzadeh
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Sep 18, 2021·Phytotherapy Research : PTR·Neda Roshanravan, Samad Ghaffari

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