PMID: 16302094Nov 23, 2005Paper

Effect of salbutamol on innervated and denervated rat soleus muscle

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
T Soić-VranićM Nikolić

Abstract

The objective of the present investigation was to perform a 14-day time-course study of treatment with salbutamol, a beta2 adrenoceptor agonist, on rat soleus muscle in order to assess fiber type selectivity in the hypertrophic response and fiber type composition. Male Wistar rats were divided into four groups: control (N = 10), treated with salbutamol (N = 30), denervated (N = 30), and treated with salbutamol after denervation (N = 30). Salbutamol was injected intraperitoneally in the rats of the 2nd and 4th groups at a concentration of 0.3 mg/kg twice a day for 2 weeks. The muscles were denervated using the crush method with pean. The animals were sacrificed 3, 6, 9, 12, and 14 days after treatment. Frozen cross-sections of soleus muscle were stained for myosin ATPase, pH 9.4. Cross-sectional area and percent of muscle fibers were analyzed morphometrically by computerized image analysis. Treatment with salbutamol induced hypertrophy of all fiber types and a higher percentage of type II fibers (21%) in the healthy rat soleus muscle. Denervation caused marked atrophy of all fibers and conversion from type I to type II muscle fibers. Denervated muscles treated with salbutamol showed a significantly larger cross-sectional area of...Continue Reading

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Citations

Apr 23, 2010·Photochemistry and Photobiology·Christopher R HayworthF Gonzalez-Lima
Dec 9, 2008·Pharmacology & Therapeutics·Stephan von HaehlingStefan D Anker
Jul 13, 2013·The International Journal of Biochemistry & Cell Biology·Olivier R JoassardDamien G Freyssenet
Nov 25, 2004·Physical Medicine and Rehabilitation Clinics of North America·Mohamed S AhmedAdrian Cristian
Jan 16, 2007·American Journal of Physiology. Cell Physiology·Z AshleyJ C Jarvis
Mar 16, 2007·Journal of Neurophysiology·Benjamin K BarryRoger M Enoka
Apr 21, 2005·Physiological Genomics·Tatiana Y KostrominovaJohn A Faulkner
Apr 11, 2020·Cellular and Molecular Neurobiology·Venera Khuzakhmetova, Ellya Bukharaeva

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