PMID: 2507027Aug 19, 1989Paper

Effect of salcatonin given intranasally on early postmenopausal bone loss

BMJ : British Medical Journal
K OvergaardM A Hansen

Abstract

To study the effect of salmon calcitonin (salcatonin) given intranasally on calcium and bone metabolism in early postmenopausal women. Double blind, placebo controlled, randomised group comparison. Outpatient clinic for research into osteoporosis. 52 Healthy women who had had a natural menopause two and a half to five years previously. The 52 women were allocated randomly to two years of treatment with either salcatonin 100IU given intranasally (n = 26) or placebo (n = 26). Both groups received a calcium supplement of 500 mg daily. Seven of the women receiving salcatonin and six of those receiving placebo left the study before its end. Bone mineral content in the spine, the total skeleton, and the forearms after two years of treatment. Bone mineral content in the spine was significantly higher in the women who had received salcatonin than in those who had received placebo both after one year and after two years of treatment. After one year the difference was 3.8% (95% confidence interval 0.0 to 7.6%) and after two years it was 8.2% (3.8 to 12.6%). In contrast, the bone mineral content in the distal and proximal forearms and in the total skeleton declined similarly in both groups by about 2% each year, and after two years of tre...Continue Reading

References

Jan 1, 1976·Clinical Endocrinology·F R SingerB G Mills
Apr 1, 1989·Clinical Endocrinology·K OvergaardJ S Johansen
Apr 23, 1988·Lancet·I MacIntyreM J Healy
Mar 1, 1985·Annals of Internal Medicine·B EttingerC E Cann
Sep 1, 1986·Calcified Tissue International·B J RiisC Christiansen
Oct 1, 1988·The Journal of Clinical Investigation·R CivitelliC Gennari
Apr 1, 1988·The American Journal of Medicine·B J Riis, C Christiansen
Mar 1, 1987·Acta Endocrinologica·J S JohansenC Christiansen
Jan 22, 1987·The New England Journal of Medicine·B RiisC Christiansen
Feb 1, 1987·Scandinavian Journal of Clinical and Laboratory Investigation·L NilasC Christiansen
Nov 5, 1987·The New England Journal of Medicine·D P KielM A Moskowitz
Jun 1, 1986·Endocrinology·C GreenbergG A Williams
Aug 1, 1980·European Journal of Clinical Investigation·C ChristiansenI Transbøl
Dec 1, 1983·European Journal of Clinical Investigation·J C StevensonM I Whitehead
Apr 1, 1984·Metabolism: Clinical and Experimental·H E GruberC H Chesnut
Sep 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·J PødenphantC Christiansen
Aug 1, 1984·Clinical Physiology·A GotfredsenR B Mazess

❮ Previous
Next ❯

Citations

Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H E van der WielW J van der Vijgh
Jan 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J Y ReginsterP Franchimont
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C Monier-FaugereH H Malluche
Aug 1, 1994·Calcified Tissue International·K Overgaard, B J Riis
Jan 1, 1992·Calcified Tissue International·H KrögerE M Alhava
Jun 1, 1995·Calcified Tissue International·J Y ReginsterP Franchimont
Apr 1, 1992·Calcified Tissue International·C GennariR Civitelli
Dec 1, 1995·Calcified Tissue International·M AzriaJ M Zanelli
Jan 1, 1994·Calcified Tissue International·G KollerupO H Sørensen
Sep 1, 1992·Calcified Tissue International·K OvergaardC Christiansen
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P SambrookJ Eisman
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J M Cardona, E Pastor
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Y Reginster
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L FlickerJ D Wark
Sep 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Y ReginsterP Franchimont
Dec 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B ClemmesenC Christiansen
Jan 1, 1995·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B J RiisC Christiansen
Oct 1, 1990·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C ChristiansenP Rødbro
Feb 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R MuffJ A Fischer
Jan 1, 1991·Calcified Tissue International·C Christiansen
Jan 1, 1991·Calcified Tissue International·L V Avioli
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C Gennari, A Camporeale
Dec 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C H ChesnutL Mindeholm
Jul 30, 2009·Wiener medizinische Wochenschrift. Supplement·Hans Peter DimaiUNKNOWN Austrian Society for Bone and Mineral Research (AuSBMR)
Apr 25, 1992·Lancet·J Y Reginster
Jun 22, 2002·Lancet·Pierre D Delmas
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·L V Avioli
Apr 1, 1997·Trends in Endocrinology and Metabolism : TEM·L V Avioli
Feb 13, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·N TangsinmankongR A Good
Aug 27, 1992·The New England Journal of Medicine·B L Riggs, L J Melton
Jun 17, 1993·The New England Journal of Medicine·P SambrookJ Eisman
Mar 12, 1998·The New England Journal of Medicine·R Eastell
Apr 8, 1999·Journal of Clinical Pathology·J SouthgateA M Flanagan
Jan 1, 1995·Annual Review of Medicine·K M PrestwoodL G Raisz
Oct 24, 2009·Arthritis Research & Therapy·Kenneth G Saag, Piet Geusens
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D PienkowskiH H Malluche

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.