Feb 1, 1980

Effect of salts on mitochondrial monoamine oxidase from bovine liver

Japanese Journal of Pharmacology
S Kobayashi, K Oguchi


The effects of various salts on the activity of mitochondrial monoamine oxidase (MAO) from bovine liver were studied by measuring the initial and long-term enzyme reactions with an oxygen electrode and Warburg's manometer, respectively, using several monoamines as substrates. Salts with a -Cl- group, such as KCl and NaCl, or with a -NO3- group, such as KNO3 and NaNO3, increased the initial MAO activity with tyramine as substrate. NaCl strongly inhibited the long-term enzyme reaction. With tyramine as substrate, NaCl increased the activity only during the first 6 to 7 min of the reaction. Similarly with beta-phenylethylamine or butylamine as substrate, NaCl increased the initial MAO activity, but decreased the activity in the long-term reaction. On the other hand, with serotonin or benzylamine as substrate, NaCl decreased both the the initial reaction and the long-term reaction. The effect of NaCl on the enzyme with tyramine as substrate was reversible, while with serotonin as substrate it was irreversible. These results indicate that the effect of NaCl depends on the substrate used and suggest that bovine liver mitochondria contain at least two different forms of MAO.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Serotonin Measurement
Bos taurus
Monoamine Oxidase [PK]
Mitochondria, Liver
Monoamine Oxidase

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.