Effect of salvianolate on migration of human vascular endothelial cells

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Jie Xu, Wei-Hu Fan

Abstract

To study the effect of salvianolate on the migration of endothelial cells induced by monocytes. Transwell-boydom system was used to test the migration of endothelial cells induced by monocytes. Enzyme-linked immunosorbent assay (ELISA) and RT-polymerase chain reaction (RT-PCR) method were used to determine the effect of salvianolate on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and their mRNA of monocytes. The migration of endothelial cells induced by monocytes was facilitated by salvianolate, compared with the control. After the monocytes were treated by salvianolate for 24 hours, the expression of mRNA of VEGF and bFGF was significantly up-regulated, and the expression of VEGF and bFGF was increased. The facilitation of salvianolate on the migration of endothelial cells induced by monocytes was observed. Salvianolate stimulates the expression of VEGF and bFGF and their mRNA of monocytes, and salvianolate may have the role of inducing migration of endothelial cells by working on these two factors.

References

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Citations

Dec 10, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Fu-guo YangGuo-xiong Dong
Feb 17, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Ming-Wei WangJun Huang
Dec 17, 2008·Journal of Personality·Frederick L PhilippeGeneviève Beaulieu-Pelletier

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