Effect of sample preparation on components and liver toxicity of Polygonum multiflorum

Journal of Pharmaceutical and Biomedical Analysis
G P LvS P Li

Abstract

It was shown that different extracts had significant differences in the toxicity of Polygonum multiflorum. In this study, the effect of sample preparation on components and liver toxicity of different extracts from P. multiflorum were determined. Hepatoxic components were discovered based on biomembrane extraction. Comparative chemistry and toxicology between ethanol and water extracts were also performed. The results showed that ethanol extract had much stronger hepatotoxicity, the content of emodin-8-O-β-d-glucopyranoside, physcion-8-O-β-d-glucopyranoside, emodin and physcion was significantly higher in ethanol extract than in water extract, while the human hepatocytes extraction showed that 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucopyranoside, emodin-8-O-β-d-glucopyranoside, physcion-8-O-β-d-glucopyranoside, emodin and physcion had interaction with human hepatocytes. The hepatotoxic effect of these components was investigated on human hepatocytes LO2 cells and emodin-8-O-β-d-glucopyranoside, physcion-8-O-β-d-glucopyranoside, emodin and physcion were finally confirmed to be, at least partial, hepatotoxic components. The results showed that sample preparation has significant effect on components in extracts of P. multiflorum ...Continue Reading

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Citations

Nov 6, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Beom-Joon Lee, Kyungjin Lee
Aug 4, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hongliang LiYibin Feng
Sep 22, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Peng ZhangYuntao Jiao
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Boyan LiuBing Zhao
Mar 22, 2019·Applied Microbiology and Biotechnology·Thanh-Tam HoSo-Young Park
Aug 27, 2019·Drug Metabolism Reviews·Bo Wen, Peter Gorycki
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Longlong XuYue Gao
Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yun WeiHao Li
Aug 20, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Le ZhangJiabo Wang
Mar 4, 2020·Acta Pharmacologica Sinica·Tai RaoDong-Sheng Ou-Yang
Aug 6, 2018·The Science of the Total Environment·Bingjie ZhangYongqiang Ma
Nov 19, 2020·International Journal of Analytical Chemistry·Nguyen Thi ThoaNguyen Tien Dat
Jan 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian-Bo YangShuang-Cheng Ma

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