PMID: 6105182Jul 1, 1980Paper

Effect of saturable binding on the pharmacokinetics of drugs: a simulation

The Journal of Pharmacy and Pharmacology
S OieT N Tozer

Abstract

The time-courses of both total and unbound drug concentrations with time were simulated under conditions of saturable binding to either plasma proteins or tissues, or both, following a single intravenous dose. The curves were either linear, convex, or concave, depending upon the extent of distribution and the intrinsic ability of an eliminating organ to remove drug from the body. Saturable binding should therefore be considered whenever data showing nonlinear semilogarithmic decline are to be interpreted.

References

Sep 1, 1979·Journal of Pharmaceutical Sciences·S Oie, T N Tozer
Jul 1, 1978·Clinical Pharmacology and Therapeutics·M GibaldiP J McNamara
Jul 30, 1978·European Journal of Clinical Pharmacology·M Gibaldi, P J McNamara
Jan 1, 1976·Drug Metabolism Reviews·W J Jusko, M Gretch
Aug 1, 1976·Clinical Pharmacology and Therapeutics·D G McDevittD G Shand
Oct 1, 1975·Clinical Pharmacology and Therapeutics·G R Wilkinson, D G Shand
Nov 26, 1973·Annals of the New York Academy of Sciences·C M KuninR Monson
Nov 26, 1973·Annals of the New York Academy of Sciences·P T SchoenemannF J Bullock
Apr 1, 1973·Journal of Pharmacokinetics and Biopharmaceutics·M RowlandG G Graham
Apr 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·P J McNamaraM Gibaldi

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Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·J BraunS Oie
Jan 1, 1983·Pharmacology & Therapeutics·J M van RossumJ P Burgers
Oct 1, 1986·Antimicrobial Agents and Chemotherapy·M N DudleyR Quintiliani
Jan 1, 1983·Drug Metabolism Reviews·G R Wilkinson
Jan 1, 1983·Drug Metabolism Reviews·H Kurz, B Fichtl
Apr 1, 1982·Kidney International·J G GambertoglioW J Amend
Dec 1, 1983·British Journal of Clinical Pharmacology·C BanfieldM Rowland
Nov 1, 1984·Journal of Clinical Pharmacology·S T ChiangJ A Hubsher
Feb 14, 2006·Biochemical Pharmacology·Donald E Mager
Aug 1, 2015·CPT: Pharmacometrics & Systems Pharmacology·P DuaP H van der Graaf
Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Mikiko ShimizuHiroyasu Ogata
Feb 1, 1984·Journal of Pharmacokinetics and Biopharmaceutics·J D Huang, S Oie
Jan 1, 1988·Biopharmaceutics & Drug Disposition·B M Emanuelsson, L K Paalzow
Oct 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·K R LeesB Whiting
Oct 10, 2007·Clinical Pharmacokinetics·Darren M Roberts, Nick A Buckley
Apr 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·S OieL Fleckenstein
Aug 1, 1988·Journal of Pharmacokinetics and Biopharmaceutics·J P ReymondW Niederberger
Dec 1, 1984·The Journal of Pharmacy and Pharmacology· Zhirkov YuA, V K Piotrovskii
Feb 1, 1988·Journal of Pharmacokinetics and Biopharmaceutics·D TrenkS Oie
Apr 1, 1986·Acta Pharmacologica Et Toxicologica·L E PedersenS N Rasmussen
Feb 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·K M GiacominiT F Blaschke
Feb 1, 1993·Journal of Pharmacokinetics and Biopharmaceutics·W R Gillespie
Apr 8, 2018·Journal of Pharmaceutical Sciences·Amelia N DeitchmanHartmut Derendorf

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