Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic β-Cells Is Inhibited by Unsaturated Oleic Acid

International Journal of Molecular Sciences
Jan SrámekJan Kovar

Abstract

It has been shown that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to apoptosis, whereas unsaturated FAs are well tolerated and are even capable of inhibiting the pro-apoptotic effect of saturated FAs. Molecular mechanisms of apoptosis induction and regulation by FAs in β-cells remain unclear; however, mitogen-activated protein (MAP) kinase and endoplasmic reticulum (ER) stress signaling pathways may be involved. In this study, we tested how unsaturated oleic acid (OA) affects the effect of saturated stearic acid (SA) on the p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) pathways as well as the ER stress signaling pathways during apoptosis induction in the human pancreatic β-cells NES2Y. We demonstrated that OA is able to inhibit all effects of SA. OA alone has only minimal or no effects on tested signaling in NES2Y cells. The point of OA inhibitory intervention in SA-induced apoptotic signaling thus seems to be located upstream of the discussed signaling pathways.

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Citations

Jul 18, 2018·American Journal of Physiology. Endocrinology and Metabolism·Kikumi D Ono-MooreSean H Adams
Jan 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Rui GuoChanghao Sun
Jul 25, 2019·International Journal of Molecular Sciences·Jan ŠrámekJan Kovář
May 1, 2021·International Journal of Molecular Sciences·Jan ŠrámekJan Kovář

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

[UNK] 2D Platinum
Image

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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