Effect of scan quality on diagnostic accuracy of spectral-domain optical coherence tomography in glaucoma

American Journal of Ophthalmology
Harsha L RaoChandra S Garudadri

Abstract

To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) parameters of spectral-domain optical coherence tomography (SD OCT) in glaucoma. Cross-sectional study. Two hundred fifty-two eyes of 183 control subjects (mean deviation [MD]: -1.84 dB) and 207 eyes of 159 glaucoma patients (MD: -7.31 dB) underwent ONH, RNFL, and GCC scanning with SD OCT. Scan quality of SD OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD OCT was evaluated by receiver operating characteristic (ROC) regression. Diagnostic accuracies of all SD OCT parameters were better when the SSI values were higher. This effect was statistically significant (P < .05) for ONH and RNFL but not for GCC parameters. In mild glaucoma (MD of -5 dB), area under ROC curve (AUC) for rim area, average RNFL thickness, and average GCC thickness parameters improved from 0.651, 0.678, and 0.726, respectively, at an SSI value of 30 to 0.873, 0.962, and 0.886, respectively, at an SSI of 70. AUCs of the same parameters in advanced glaucoma (MD of -15 dB) improved from 0.747, 0.890, and 0.873, respectively, at an SSI value of 30 t...Continue Reading

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Jan 24, 2012·Investigative Ophthalmology & Visual Science·Harsha L RaoChandra S Garudadri

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Citations

Jul 26, 2015·Neuroimaging Clinics of North America·Jade S SchiffmanRosa A Tang
Jul 1, 2016·Current Eye Research·Khalil Ghasemi FalavarjaniFoad Amirkourjani
Jun 7, 2019·Cornea·Sepehr Feizi
Nov 30, 2016·Current Opinion in Ophthalmology·Mohamed S SayedRichard K Lee
Jun 9, 2020·Current Eye Research·Leyla HazarKadri Atay
Dec 12, 2020·American Journal of Ophthalmology·S RamyashriChandrasekhar Garudadri

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