Effect of Scan Size on Glaucoma Diagnostic Performance Using OCT Angiography En Face Images of the Radial Peripapillary Capillaries

Journal of Glaucoma
Ryuna ChangGrace M Richter

Abstract

When comparing 4.5×4.5 mm to 6.0×6.0 mm optical coherence tomography angiography scans of the radial peripapillary capillaries (RPCs) for glaucoma diagnostic capability, there was a trend of 4.5 scans outperforming 6.0 scans, especially for inferior, nasal, and superior quadrants. The main purpose of this study was to compare diagnostic ability of peripapillary vessel parameters from 4.5×4.5 mm (4.5) and 6.0×6.0 mm (6.0) spectral-domain optical coherence tomography angiography scans of the RPC in detecting primary open-angle glaucoma from nonglaucoma eyes. Consecutive patients from an academic glaucoma clinic underwent 4.5 and 6.0 scans (CIRRUS HD-OCT 5000 with AngioPlex OCT Angiography; ZEISS, Dublin, CA). Automatic segmentation created en face RPC images. Vessel area density, vessel skeleton density, and flux were calculated using custom quantification software, and perfusion density and flux index (FI) using automated quantification software. Area under the curve statistics included age and hypertension in the analysis. Of 173 eyes from 123 patients who underwent both 4.5 and 6.0 imaging, 32 primary open-angle glaucoma eyes from 32 patients and 95 nonglaucoma eyes from 95 patients were studied. For the global region of 4.5 v...Continue Reading

References

May 26, 2004·Lancet·Robert N Weinreb, Peng Tee Khaw
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Mar 14, 2012·Investigative Ophthalmology & Visual Science·Young Hoon Hwang, Yong Yeon Kim
Mar 28, 2013·Investigative Ophthalmology & Visual Science·Renato LisboaFelipe A Medeiros
Jun 1, 2013·Investigative Ophthalmology & Visual Science·Jin Wook JeoungDong Myung Kim
Dec 21, 2013·The British Journal of Ophthalmology·Igor I BusselJoel S Schuman
May 16, 2014·JAMA : the Journal of the American Medical Association·Robert N WeinrebFelipe A Medeiros
Jul 24, 2015·JAMA Ophthalmology·Liang LiuDavid Huang
Aug 11, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaolei WangXinghuai Sun
Jun 11, 2016·Journal of Biomedical Optics·Zhongdi ChuRuikang K Wang
Jul 15, 2016·Investigative Ophthalmology & Visual Science·Adeleh YarmohammadiRobert N Weinreb
Sep 4, 2016·American Journal of Ophthalmology·Harsha L RaoCarroll A B Webers
Aug 2, 2017·Progress in Retinal and Eye Research·Amir H KashaniRuikang K Wang

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Methods Mentioned

BETA
imaging technique

Software Mentioned

CIRRUS
MATLAB
ZEISS
OCTA
STATA
SAS
Excel

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