Effect of Scopolamine on Mice Motor Activity, Lick Behavior and Reversal Learning in the IntelliCage

Neurochemical Research
Péter Pelsőczi, György Lévay

Abstract

Automated homecage monitoring systems are now widely recognized and used tools in cognitive neuroscience. However, few of these studies cover pharmacological interventions. Scopolamine, an anticholinergic memory disrupting agent is frequently used to study learning behavior. We studied the impact of scopolamine treatment in a relevant dose-range on activity, drinking behavior and reversal learning of C57BL/DJ mice in a homecage-like, social environment, using the IntelliCage. Naïve mice were first habituated to the IntelliCage, where they learned to nosepoke in any of the four corners in order to gain access to the water reward. Visits, nosepokes, lick numbers and durations were recorded. Mice were then trained to distinguish between a rewarded correct corner and punished, incorrect corners. Later, in the reversal learning phase, the assigned correct corner was rotated clockwise every 24 h. Upon s.c. administration of scopolamine general activity represented by visit and nosepoke numbers increased, but their durations were shorter. Surprisingly, general activity and lick behavior were drastically altered. Scopolamine also significantly reduced the ability to perform a reversal learning task. We not only found significant declin...Continue Reading

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Citations

Mar 29, 2020·Brain and Neuroscience Advances·Matthew P WilkinsonEmma S J Robinson
Jun 27, 2021·Psychopharmacology·Elpidio Attoh-MensahPascale Schumann-Bard

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Software Mentioned

GraphPad
IntelliCage Plus
GraphPad Prism
IntelliCage
IntelliCages

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