PMID: 1200155Nov 1, 1975Paper

Effect of secretin and cholecystokinin on small intestinal blood flow distribution

The American Journal of Physiology
J W Fara, K S Madden

Abstract

The relative blood flow distribution within the small intestine of anesthetized cats was investigated during resting conditions and when superior mesenteric blood flow was increased 15--85% by the intravenous infusion of secretin, cholecystokinin (CCK), or isoproterenol. Radioactive microspheres of 15 mum diameter were injected into the superior mesenteric artery and shortly thereafter intestinal segments were removed and dissected into mucosal, submucosal, and muscularis fractions. Tissue weights and the radioactivity of each were determined. During secretin-induced mesenteric vasodilatation there was a significant redistribution of blood away from the jejunal mucosa to the submucosa. During CCK and isoproterenol infusions there were significant increases in mucosal and decreases in submucosal blood flow. No significant changes were observed in muscularis flow. There was no apparent relationship between the percent increase in SMBF and the relative blood flow distribution changes observed. The results indicate that while secretin, CCK, and isoproterenol increase superior mesenteric blood flow, they also affect blood flow distribution within the mucosa and submucosa.

Citations

Nov 1, 1981·Digestive Diseases and Sciences·M G SarrS F Phillips
Jul 12, 2016·Pancreas·Karoly HorvathZhaoping He
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·I BenyóG Szabó
Jul 1, 1978·Zentralblatt für Veterinärmedizin. Reihe A·A HouvenaghelL Wechsung
Oct 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniela M SartorAnthony J M Verberne
Sep 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John StephensDouglas G Burrin
Jan 1, 1986·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·U Finke, J Seifert
Oct 10, 2013·Molecular Nutrition & Food Research·Noriyasu KontaniKousaku Ohinata
Oct 1, 1995·British Journal of Pharmacology·A HeinemannP Holzer
Sep 5, 2012·Molecular Nutrition & Food Research·Tomomi KagebayashiKousaku Ohinata
Sep 12, 1996·Journal of the Autonomic Nervous System·S LucchiniL Garnier
Jul 17, 2004·Regulatory Peptides·Cristina Sánchez-FernándezMaría S Fernández-Alfonso
Aug 8, 2006·Regulatory Peptides·Mariano Ruiz-GayoSoledad Fernández-Alfonso
Jul 29, 2008·Brain Research Reviews·Daniela M Sartor, Anthony J M Verberne
Oct 15, 2010·Kidney International·Jessica Y S ChuBilly K C Chow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.