PMID: 565310Apr 1, 1978

Effect of secretin on basal- and glucose-stimulated insulin secretion in man

J FahrenkrugC Kühl


Plasma immunoreactive secretin and insulin concentrations were measured in fasting normal humans after intraduodenal infusions of hydrochloric acid, isotonic or hypertonic glucose. The effect of intraduodenal acidification or intravenous bolus injections of secretin on plasma insulin concentrations during infusions of glucose was also examined. The intraduodenal glucose load did not cause an increase in plasma secretin concentrations. Secretin concentrations rose after acid both in the fasting state and during infusions of glucose. A concomitant rise in insulin levels was however only observed during infusions of glucose. Intravenous injection of secretin in a dose which mimicked the response to intraduodenal acidification was without effect on the glucose-stimulated insulin release, while a 30 times higher dose caused a highly significant augmentation of the insulin release. The insulin response pattern to this high dose of secretin differed completely from that observed after intraduodenal infusion of acid. It is concluded and confirmed that the stimulating effect of secretin on insulin secretion is pharmacological and that secretin plays no significant role in the entero-insular axis.


Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
Feb 1, 1979·Diabetologia·W Creutzfeldt
Dec 1, 1986·Acta Physiologica Scandinavica·B Ahrén, I Lundquist
May 27, 2010·Journal of Endocrinological Investigation·D H St-Pierre, F Broglio
Sep 20, 1979·World Journal of Surgery·W Creutzfeldt, R Arnold
Dec 19, 2012·General and Comparative Endocrinology·Revathi Sekar, Billy K C Chow
Jan 1, 1987·Diabetes/metabolism Reviews·R Ebert, W Creutzfeldt
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jens Juul Holst, Jesper Gromada
Aug 1, 2018·Frontiers in Endocrinology·Jens F Rehfeld
Feb 5, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ida M ModvigJens J Holst
May 14, 2019·Frontiers in Endocrinology·Jens Juul Holst


Jul 1, 1976·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O B de MuckadellC Kühl
Nov 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·O B de Muckadell, J Fahrenkrug
Jan 1, 1977·Scandinavian Journal of Gastroenterology·J FahrenkrugJens Juul Holst
Sep 1, 1978·Gut·O B Schaffalitzky de Muckadell, J Fahrenkrug
Jun 1, 1977·European Journal of Clinical Investigation·J Fahrenkrug, O B Schaffalitzky de Muckadell
Jan 1, 1977·Scandinavian Journal of Gastroenterology·O B Schaffalitzky de MuckadellK B Lauritsen
Apr 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·O B Schaffalitzky de Muckadell, J Fahrenkrug
Apr 1, 1977·Brain Research·J FahrenkrugA Fahrenkrug
May 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·J FahrenkrugJens F Rehfeld
May 1, 1976·Diabetologia·F A O'ConnorM Shahidullah
Apr 1, 1967·The Journal of Clinical Investigation·R H UngerA M Eisentraut
Feb 1, 1974·Endocrinologia Japonica·K Shima, S Tarui
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Jun 10, 1967·British Medical Journal·D R BoynsH Keen
Dec 1, 1967·The Journal of Clinical Investigation·M J Perley, D M Kipnis
Jul 4, 1964·Lancet·N MCINTYRED S TURNER

Related Concepts

Intravenous Injections
Secretin Measurement
Intravenous Bolus
Glucose, (beta-D)-Isomer
Acidification - ActCode
Insulin Secretion
Insulin Measurement

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