PMID: 17563Jun 1, 1977

Effect of secretin on plasma motilin in man

P MitzneggL Demling


Graded doses of 0-1, 0-3, 0-9, and 2-7 clinical units/kg/h of pure synthetic secretin were infused over 60 minute periods in six healthy volunteers. Duodenal bicarbonate output and pH were recorded and plasma secretin and motilin levels were measured by radioimmunoassay. During the infusions plasma motilin fell in a dose dependent manner to a nadir of 35%. This fall was linearly correlated with pancreatic bicarbonate output, whereas a non-linear correlation was observed between plasma motilin and both plasma secretin level and duodenal pH. It is suggested that plasma motilin levels are decreased by secretin-induced pancreatic bicarbonate juice flow. This may be important for the control of motilin secretion initiated by duodenal acidification and the concomitant delay in gastric emptying.


May 1, 1977·The American Journal of Digestive Diseases·W Domschke
Sep 1, 1978·The American Journal of Digestive Diseases·H S OrmsbeeG L Telford
Jun 20, 2007·International Journal of Colorectal Disease·Amosy E M'KomaAlan J Herline
Jan 1, 1981·Regulatory Peptides·K MoriH Imura
Oct 1, 1983·Scandinavian Journal of Gastroenterology·J E VarhaugJ Lekven
Mar 5, 2004·Expert Opinion on Pharmacotherapy·Janet K KernMadhukar H Trivedi
Dec 1, 1986·British Journal of Obstetrics and Gynaecology·M A KhanK S Stewart
Jan 1, 1994·Acta neurochirurgica·U Albert-Niedler, H Arnold
Nov 1, 1991·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Michael KroiherStefan Berking
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack


Apr 24, 1976·Lancet·P MitzneggL Demling
Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M KappelgaardJ Giese
Jan 1, 1973·Klinische Wochenschrift·P LehnertH L Martens
Sep 1, 1972·Annals of Surgery·J C ThompsonE N Brandt

Related Concepts

Secretin Measurement
Carbonic Acid Ions
Acidification - ActCode
Gastric Emptying
Process of Secretion
Enteric Hormones
Bicarbonate Measurement

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