Effect of seizure on hippocampus in mesial temporal lobe epilepsy and neocortical epilepsy: an MRS study

Neuroradiology
S K LeeK H Chang

Abstract

This study was performed to evaluate the effect of seizures on the bilateral hippocampus in mesial temporal lobe epilepsy (mTLE) and neocortical epilepsy by single voxel proton magnetic resonance spectroscopy (MRS). Forty-one patients with mTLE having unilateral hippocampal sclerosis and 43 patients with a neocortical epilepsy who underwent subsequent epilepsy surgery were recruited. Ninety-five percent confidence intervals of N-acetyl aspartate/choline (NAA/Cho) and NAA/creatine (NAA/Cr) ratios in 20 healthy control subjects were used as threshold values to determine abnormal NAA/Cho and NAA/Cr. NAA/Cho and NAA/Cr were significantly lower in the ipsilateral hippocampus of mTLE and neocortical epilepsy. Using asymmetry indices for patients with bilaterally abnormal ratios of NAA/Cho and NAA/Cr in addition to using unilateral abnormal ratio, the seizure focus was correctly lateralized in 65.9% of patients with mTLE and 48.8% of neocortical epilepsy patients. Bilateral NAA/Cho abnormality was significantly related to a poor surgical outcome in mTLE. No significant relationship was found between the results of NAA/Cho or NAA/Cr and surgical outcome in neocortical epilepsy. The mean contralateral NAA/Cr ratio of the hippocampus in ...Continue Reading

References

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Citations

Mar 14, 2009·The Neurologist·Mar CarreñoRocío Sánchez-Carpintero
Jan 30, 2009·Epilepsia·Stefano MelettiPaolo Nichelli
Jun 4, 2010·Expert Review of Neurotherapeutics·Mark Richardson
Feb 27, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark Richardson
May 24, 2015·Neuroscience and Biobehavioral Reviews·Giulia Monti, Stefano Meletti
Jun 6, 2007·Neurochemical Research·Zhao Wei LiuZhuo Yang
Apr 15, 2021·Neuroradiology·Nadín Fernández-VegaNatalia García-Casares

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