Effect of selected denervations on glycoconjugate composition and tissue morphology during the initiation phase of limb regeneration in adult Ambystoma

The Anatomical Record
H E YoungR R Markwald

Abstract

This study was undertaken to assess the effects of various quantities of neural tissue on the temporal relationship of matrix glycoconjugates to the regeneration morphology. 1) Denervation before amputation revealed that a threshold level of nervous tissue was necessary to activate a regeneration response from the tissue, i.e., appearance of regeneration-specific morphologies and glycoconjugates. 2) Denervation after amputation demonstrated that the level of neural tissue necessary to maintain these responses was below the level necessary to activate the regeneration response. If neural tissue was completely removed there was a concomitant loss of regenerate morphologies and glycoconjugates. 3) Bilateral amputation of a neurogenically intact limb and its completely denervated contralateral limb revealed that the regeneration response was a localized phenomenon during the first 30 days after amputation. After 30 days the regeneration response appeared within the previously degenerated denervating limb. The results suggest that the factors controlling the regenerative response in adult Ambystoma are large diffusible substances that can be transported by the circulation and can affect the regenerative response in remote, previousl...Continue Reading

References

Jun 1, 1985·The Anatomical Record·H E YoungB K Dalley
Jan 1, 1986·Developmental Biology·M J KujawaA I Caplan
Jan 1, 1982·Differentiation; Research in Biological Diversity·L A RepeshL T Furcht
Nov 7, 1982·Journal of Theoretical Biology·M J BissellG Parry
Aug 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L A RepeshD Smith

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Citations

Feb 26, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Henry E YoungAsa C Black
Jan 5, 2018·Regeneration·David L Stocum
Sep 1, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jihong CuiFulin Chen
Oct 12, 2018·Developmental Neurobiology·David L Stocum
Dec 15, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jeffrey T Laitman, Kurt H Albertine

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