PMID: 7085044Mar 1, 1982Paper

Effect of selected immunoregulatory agents on low-grade contact sensitivity

Inflammation
D E Griswold, D T Walz

Abstract

The effect of selected compounds with known immunoregulatory activity was examined in a 45-h sensitization period oxazolone contact-sensitivity reaction. Oxazolone sensitivity was induced by applying 0.1 ml of 5% oxazolone in absolute ethanol to the shaved abdomen of C57Bl/6 mice on day 0. Challenge with oxazolone followed 45 h later and was accomplished by painting a 5% solution of oxazolone in absolute ethanol on the left hindpaw. The response at 24 h was determined plethysmographically. Histamine (0.062-1.0 mg/kg, subcutaneously, twice a day), concanavalin A (0.31-5.0 mg/kg intravenously), penicillamine (6.25-25 mg/kg, subcutaneously), chloroquine (6.25-25 mg/kg, subcutaneously), and thymosin fraction 5 (0.125-1.25 mg/kg subcutaneously) all stimulated the oxazolone reaction when administered on day 0. These data suggest that the low-grade oxazolone response may be a useful assay to detect immunostimulatory activity.

References

Jan 1, 1979·Journal of Immunopharmacology·J F Bach
May 1, 1976·British Medical Bulletin·G L Asherson, M Zembala
Jun 1, 1976·Annals of the Rheumatic Diseases·A E FinkelsteinA Misher
Feb 28, 1975·Annals of the New York Academy of Sciences·N TalalR Goldblum
Nov 1, 1972·The Journal of Experimental Medicine·G M ShearerM Sela
Oct 1, 1972·Toxicon : Official Journal of the International Society on Toxinology·J SvihovecZ Jiricka
Mar 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·D T WalzW Zuccarello
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May 15, 1981·Cellular Immunology·A SchwartzR K Gershon
Jan 1, 1982·International Archives of Allergy and Applied Immunology·D E GriswoldD T Walz

Citations

Dec 1, 1992·Pharmacology & Therapeutics·J G BowenI M Hunneyball
May 1, 1996·International Journal of Immunopharmacology·T KashidaS Takeyama
Sep 1, 1984·Journal of Pharmacological Methods·E F Webb, D E Griswold

Related Concepts

Immunologic Adjuvants
Metazoa
Nivaquine
Contact Hypersensitivity
Dose-Response Relationship, Drug
Ceplene
Mice, Inbred C57BL
Oxazolone
Metalcaptase
Thymosin Fs

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