Effect of Selected Stilbenoids on Human Fecal Microbiota

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jose D JaimesJaroslav Havlik

Abstract

Dietary phenolics or polyphenols are mostly metabolized by the human gut microbiota. These metabolites appear to confer the beneficial health effects attributed to phenolics. Microbial composition affects the type of metabolites produced. Reciprocally, phenolics modulate microbial composition. Understanding this relationship could be used to positively impact health by phenolic supplementation and thus create favorable colonic conditions. This study explored the effect of six stilbenoids (batatasin III, oxyresveratrol, piceatannol, pinostilbene, resveratrol, thunalbene) on the gut microbiota composition. Stilbenoids were anaerobically fermented with fecal bacteria from four donors, samples were collected at 0 and 24 h, and effects on the microbiota were assessed by 16S rRNA gene sequencing. Statistical tests identified affected microbes at three taxonomic levels. Observed microbial composition modulation by stilbenoids included a decrease in the Firmicutes to Bacteroidetes ratio, a decrease in the relative abundance of strains from the genus Clostridium, and effects on the family Lachnospiraceae. A frequently observed effect was a further decrease of the relative abundance when compared to the control. An opposite effect to the...Continue Reading

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Citations

Mar 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika JarosovaJaroslav Havlik
May 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meenakshi Sudhakaran, Andrea I Doseff
Jul 1, 2021·Journal of Ethnopharmacology·Lindiwe SibekoLorraine S Cordeiro
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kittisak Likhitwitayawuid
May 13, 2020·Journal of Agricultural and Food Chemistry·NIan ZhouMingmei Zhou

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Methods Mentioned

BETA
PCR
Chip

Software Mentioned

QIIME
SPSS

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