Effect of selective inhibitor of thromboxane A2 synthetase on cerebral vasospasm after early surgery

Journal of Neurosurgery
E TaniT Matsumoto

Abstract

The authors report the results of inhibition of thromboxane A2 synthetase in 49 consecutive patients with subarachnoid hemorrhage (SAH). These unselected Grade I to IV patients all had a ruptured aneurysm of the anterior circle of Willis, and were operated on within 72 hours after SAH. Twenty-seven patients were treated postoperatively by an intravenous infusion of sodium (E)-3- [4-(3-pyridylmethyl)-phenyl] -2- propenoate (OKY-1581), a selective inhibitor of thromboxane A2 synthetase, at 5 micrograms/kg/min for 10 to 14 days, and the remaining 22 patients did not receive this drug. Both groups of patients had similar age distribution and preoperative neurological conditions. A suggestive but statistically insignificant improvement was found in postoperative angiographic vasospasm, ischemic symptoms, and overall outcome in the group receiving OKY-1581. The incidence of low-density areas on the postoperative computerized tomography scans was significantly decreased in patients treated with OKY-1581 infusion.

References

Jan 1, 1977·Stroke; a Journal of Cerebral Circulation·J AstrupN A Lassen
Mar 1, 1975·Lancet·B Jennett, M Bond
Jun 15, 1977·European Journal of Pharmacology·J D PickardA M Harper
Jan 1, 1979·Clinical Neurosurgery·S J Peerless
Jan 1, 1977·Clinical Neurosurgery·W E Hunt, C A Miller
Jan 1, 1975·Stroke; a Journal of Cerebral Circulation·R P WhiteJ T Robertson
Sep 1, 1975·Stroke; a Journal of Cerebral Circulation·L SymonJ Juhasz
Oct 1, 1972·Journal of Neurosurgery·Y L YamamotoC P Hodge
Jul 1, 1983·Prostaglandins, Leukotrienes, and Medicine·W KrauseM Totzek
Nov 1, 1983·Journal of Neurosurgery·T FukumoriA Sukenaga
Mar 1, 1984·Stroke; a Journal of Cerebral Circulation·T FukumoriA Sukenaga
Apr 1, 1983·Journal of Neurosurgery·B WheelockB Benoit
Jul 1, 1982·Stroke; a Journal of Cerebral Circulation·E ShohamiS Lavy
Feb 1, 1982·Journal of Neurosurgery·H Hugenholtz, R G Elgie
Apr 1, 1981·Journal of Neurosurgery·B LjunggrenG Sundbärg
Nov 1, 1981·Journal of Neurosurgery·Y MaedaT Miyamoto
Feb 1, 1981·Journal of Neurosurgery·B Weir, K Aronyk

❮ Previous
Next ❯

Citations

Nov 1, 1986·Journal of Neurosurgery·J T Hoff
Nov 1, 1989·Journal of Neurosurgery·R T HigashidaG B Hieshima
Jan 1, 1990·Journal of Neurotrauma·D D'AvellaF Tomasello
Nov 1, 1993·Stroke; a Journal of Cerebral Circulation·H ParfenovaC W Leffler
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·N F KassellG Nazar
Apr 1, 1991·Stroke; a Journal of Cerebral Circulation·S JuvelaM Kaste
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·R L Macdonald, B K Weir
Jul 26, 2003·Stroke; a Journal of Cerebral Circulation·Sanne M Dorhout MeesJan van Gijn
Oct 26, 2014·The Journal of Pharmacology and Experimental Therapeutics·Gábor RaffaiPaul M Vanhoutte
Oct 19, 2007·The Cochrane Database of Systematic Reviews·S M Dorhout MeesG J E Rinkel
Apr 1, 1994·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·N W Dorsch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.