PMID: 9417490Jan 7, 1998Paper

Effect of selenium administration on various laboratory parameters in patients with acute pancreatitis

Medizinische Klinik
S WollschlägerH Porst

Abstract

Recent studies presented evidence that activation of oxygen derived free radicals occurs in patients with acute pancreatitis. The purpose of this study was to evaluate the effect of sodium selenite as a possible antioxidant therapy in acute pancreatitis. 16 patients with moderate form of acute pancreatitis received a high dose of sodium selenite. Selenium in serum and whole blood, zinc, copper, manganese, superoxid dismutase (SOD), glutathione peroxidase (Gpx) and malondialdehyde (MDA) were determined (before selenium substitution, 3 days later, 8 days later, before demission). No selenium deficiency could be detected before selenium substitution. The selenium therapy caused a significant increase in selenium, a moderate increase in activity of Gpx, a significant decrease in activity of MDA, whereas SOD remained unchanged. Concerning the particular point of view of "deficiency management", there is no need of selenium substitution in patients with a moderate form of acute pancreatitis in our region. The highly normal selenium concentration we established by our therapy is possibly connected with a decrease of the oxidative stress in acute pancreatitis. More clinical follow-up studies with more patients, who have different grade...Continue Reading

References

May 1, 1994·Digestive Diseases and Sciences·M H SchoenbergH G Beger
Feb 1, 1996·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J PeraltaJ J Poderoso
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·J H Sweiry, G E Mann

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Citations

Aug 21, 2013·Free Radical Research·J A ArmstrongD N Criddle
Jul 28, 2015·The Cochrane Database of Systematic Reviews·Mikkel Allingstrup, Arash Afshari

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