PMID: 2484400Apr 1, 1989Paper

Effect of selenium on the growth of three human colon cancer cell lines

Biological Trace Element Research
J L NanoP Rampal

Abstract

The effects of selenium were investigated on three human colon cancer cell lines: Caco 2, HRT 18, and HT 29. At low concentrations (10-100 nM), selenium stimulated cell growth in serum-free medium. Thus, selenium is an essential trace element for cell proliferation. At higher concentrations, selenium inhibited cell growth. The rate of 75Se uptake was the same in all of the cell lines studied, but the quantity incorporated differed. GSH-Px activity was dependent on the selenium content of the medium. DNA and protein synthesis paralleled the growth curve. Comparison with the curve of viability revealed that selenium inhibited cell growth in two ways: by inhibiting DNA synthesis, without affecting cell viability, and, at higher doses, by cytotoxicity.

References

Jul 1, 1977·Journal of the National Cancer Institute·J FoghT Orfeo
Jan 1, 1979·Methods in Enzymology·J BottensteinR Wu
Aug 1, 1979·Archives of Biochemistry and Biophysics·A S Giasuddin, A T Diplock
Nov 7, 1977·Biochemical and Biophysical Research Communications·G S Germain, R M Arneson
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W L McKeehanR G Ham
Jul 31, 1985·Biochemical and Biophysical Research Communications·M M WebberG T James
Oct 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·W M Lewko, K P McConnell
Aug 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J F Gregory, G T Edds
Sep 1, 1984·American Journal of Epidemiology·J T SalonenP Puska
Nov 1, 1984·Cancer Letters·A M WatrachK A Poirier

❮ Previous
Next ❯

Citations

Mar 26, 1998·Diseases of the Colon and Rectum·D PsathakisH P Bruch
Dec 25, 2009·Archives of Toxicology·Vanessa ValdiglesiasBlanca Laffon
Jan 5, 2014·Chemical Research in Toxicology·Simona ConstantinescuNiko Beerenwinkel
Jan 1, 1997·Nutrition and Cancer·M W RussoR S Sandler
Nov 7, 2009·Reviews on Environmental Health·Marco VincetiCarlotta Malagoli
Oct 9, 2013·Applied Biochemistry and Biotechnology·Yong JiaChuan-Chao Dai
Feb 1, 1993·Biological Trace Element Research·E BahbouthR Bassleer
Jun 1, 1993·Japanese Journal of Cancer Research : Gann·A HaraM Tsuchiya
Jan 22, 2002·Nutrition and Cancer·Y S Kim, J Milner
Jun 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R H Goodwin
Jun 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·S M Ferkovich, H Oberlander
Jul 1, 1995·In Vitro Cellular & Developmental Biology. Animal·W H TsaiA S Chiang
Jun 14, 2003·Biochemical and Biophysical Research Communications·B HusbeckG Powis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.