PMID: 30234183Sep 21, 2018Paper

Effect of senescence on some apoptosis and oxidative stress markers in infertile normozospermic and oligospermic men: A cross-sectional study

International Journal of Reproductive Biomedicine
Mathias Abiodun Emokpae, Happy Ngozi Chima

Abstract

Male senescence may affect testicular function, sperm indices and generation of high levels of oxidants and apoptosis. This study evaluates the effect of male age on the expression of some apoptosis and oxidative stress markers in seminal fluid of males investigated for infertility in a tertiary health institution in Nigeria. In this cross-sectional study, 122 men aged 20-60 yr who were investigated for infertility and were stratified according to age into four groups. Seminal plasma caspase 3, cytochrome C, and total antioxidant capacity (TAC) were assayed by ELISA technique, while manual semen analysis was performed according to WHO standard. Seminal caspase 3, and cytochrome C activity increased while TAC and sperm indices decreased with increasing age. Cytochrome C (r=0.288; p=0.002) and caspase 3 (r=0.250; p=0.05) correlated significantly with age in normospermia while cytochrome C (r=0.314; p=0.02), caspase 3 (r=0.268; p=0.05), TAC (r=-0.342; p=0.01) and morphology percentage (r=-0.414; p=0.002) correlated with age in oligospermic infertile males. The measured apoptotic markers increased with increasing age while TAC and sperm indices decreased with increasing age of subjects evaluated. Although the levels of measured apo...Continue Reading

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Zhonghua nan ke xue = National journal of andrology
Yi-chao ShiYu-feng Huang
Ginekologia polska
D Robak-ChołubekM Bokiniec
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
B GürbüzK Zehir
© 2022 Meta ULC. All rights reserved