Effect of sensory neuropeptides on canine bronchial and pulmonary vessels in vitro.

Life Sciences
D G McCormackP J Barnes

Abstract

Sensory neuropeptides may be important in the noncholinergic component of parasympathetic vasodilation in the tracheobronchial circulation. We studied the effects of substance P (SP), neurokinin A (NKA), neurokinin B (NKB) and calcitonin gene-related peptide (CGRP) on the isolated canine bronchial artery and used pulmonary artery and vein of similar size for comparison. CGRP (10pM-300nM) was a potent relaxant of the bronchial and pulmonary arteries, and the pulmonary vein with equal potency in all vessels. SP in low concentrations (10pM-100nM) caused vasodilation of the precontracted bronchial artery and in high concentration (10-100 microM) contracted the vessel from resting tone. SP also relaxed the pulmonary artery and vein. NKA and NKB caused relaxation in all three vessels. All of the vascular effects of the sensory neuropeptides were concentration-dependent. The order of potency of the neuropeptides in the bronchial and pulmonary artery was SP greater than NKA greater than CGRP greater than NKB. In the pulmonary vein NKB caused a much larger relaxation than SP and NKA but it was less potent than either NKA or CGRP. Capsaicin (1 microM) caused a large contraction of the bronchial artery, similar in magnitude to the contrac...Continue Reading

References

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Citations

Jan 1, 1991·Annals of the New York Academy of Sciences·P J Barnes
Jul 7, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D WarburtonK Anderson
Mar 1, 1992·Experimental Lung Research·I M Keith, R Ekman
Sep 2, 2006·Vascular Pharmacology·Brendan J Canning
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P J Barnes
Sep 29, 1999·Pulmonary Pharmacology & Therapeutics·R W ChapmanS Young
May 16, 2002·Chest·Manuel G CosioMonica G Cosio
May 14, 2004·Current Opinion in Pharmacology·Azzeddine DakhamaErwin W Gelfand
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Jan 14, 1999·Journal of Applied Physiology·T E PisarriH M Coleridge
Nov 5, 1997·The Journal of Surgical Research·C C CanverR Saban

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