Effect of sensory stimulus on striatal dopamine release in humans and cats: a [(11)C]raclopride PET study

Neuroscience Letters
Stephane ThoboisVincent Leviel

Abstract

Sensory stimulation of the forelimb extremities constitutes a well-established experimental model that has consistently shown to activate dopamine (DA) neurotransmission in the mammals' forebrain. To visualize in vivo this modification of striatal DA release in healthy human volunteers using Positron Emission Tomography (PET) and [(11)C]raclopride. Experiments in humans were paralleled by experiments in anesthetized cats. Changes in endogenous DA release were assessed through its competition with [(11)C]raclopride binding (BP(raclo)), a radioligand probing DA D2-receptors. In humans no significant difference of BP(raclo) in caudate (with sensory stimulation: 2.0 +/- 0.3 versus without sensory stimulation: 2.2 +/- 0.3; P = 0.3) or putamen (2.6 +/- 0.3 versus 2.6 +/- 0.2; P = 0.9) ipsilateral to the stimulus was disclosed as a result of sensory stimulation. Similarly, no change of BP(raclo) was observed contralaterally to the stimulation in the caudate nucleus (with sensory stimulation: 2.0 +/- 0.4 versus without sensory stimulation: 2.1 +/- 0.2; P = 0.5) and the putamen (2.5 +/- 0.4 versus 2.6 +/- 0.2; P = 0.4). In cats the same results were obtained in the ipsilateral to stimulation striatum (with sensory stimulation: 2.5 +/- 0...Continue Reading

References

Sep 22, 1977·Nature·A NieoullonJ Glowinski
Sep 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·A Fink-JensenA J Hansen
Jan 1, 1993·Progress in Biophysics and Molecular Biology·M Fillenz
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Mar 30, 1999·Nuclear Medicine and Biology·R M MorescoB Maziere
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Laruelle
Jun 5, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yasuomi OuchiMasanobu Sakamoto
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jens C PruessnerAlain Dagher

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Citations

Jun 7, 2005·Neuroscience Letters·Wadad HassounVincent Leviel
Jun 19, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Eman M KhedrAhmed Hamdy

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