PMID: 11910616Mar 26, 2002Paper

Effect of sequential transdermal progesterone cream on endometrium, bleeding pattern, and plasma progesterone and salivary progesterone levels in postmenopausal women

Climacteric : the Journal of the International Menopause Society
B G WrenJ A Eden

Abstract

Transdermal progesterone is being used in some countries as a purported treatment for menopausal symptoms, either alone or prescribed in conjunction with estrogen, but little information exists regarding the biological activity and effectiveness of this method of delivery of progesterone in protecting the endometrium from excess proliferation. This study was designed to evaluate the use of sequential transdermal progesterone. End-points evaluated included endometrial cellular response and bleeding pattern as well as plasma hormone levels and salivary progesterone estimations. Twenty-seven postmenopausal women were treated with continuous transdermal estrogen (28-day cycle) and a cream containing 16, 32 or 64 mg of progesterone in each 4-cm extrusion from a tube of Pro-Feme administered daily in a sequential (days 15-28 of cycle) regimen. Blood and endometrial samples were analyzed for progesterone response prior to therapy, after the first 14 days of unopposed transdermal estrogen and following 14 days of transdermal progesterone. Saliva samples were taken during the last 14 days of the 84-day study, when the final progesterone cream therapy was being applied. Hormone assay indicated that physiological levels of estradiol were ...Continue Reading

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Citations

Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·D W Sturdee
Mar 18, 2005·Menopause : the Journal of the North American Menopause Society·Frank Z StanczykSubir Roy
Nov 14, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M A A Elshafie, A A A Ewies
Jan 25, 2003·Menopause : the Journal of the North American Menopause Society·R Don Gambrell
Dec 1, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John W SchmidtLinda S Kim
Jul 14, 2007·Journal of Women's Health·Michael Cirigliano
Sep 10, 2014·Climacteric : the Journal of the International Menopause Society·F Z Stanczyk
May 17, 2017·Climacteric : the Journal of the International Menopause Society·M L'Hermite
Nov 21, 2019·Journal of Alzheimer's Disease : JAD·Katrine Yare, Michael Woodward
Jun 10, 2016·Climacteric : the Journal of the International Menopause Society·P StuteL Wildt
May 7, 2015·Menopause : the Journal of the North American Menopause Society·James H PickarBrian Bernick
Jan 7, 2021·Climacteric : the Journal of the International Menopause Society·F Z StanczykS A Winer
May 29, 2004·Menopause : the Journal of the North American Menopause Society·Lisa A BoothbySimon Kipersztok
Mar 8, 2005·The Medical Journal of Australia·Barry G Wren
Apr 16, 2021·Endocrine Reviews·Valerie A FloresJoAnn E Manson

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