PMID: 9435128Jan 22, 1998Paper

Effect of SERCA pump inhibitors on chemoresponses in Paramecium

The Journal of Eukaryotic Microbiology
J J WassenbergD L Nelson

Abstract

Inhibitors of SERCA (sarcoplasmic/endoplasmic reticulum Ca(2+)-dependent ATPase) calcium pumps were used to investigate the involvement of internal Ca2+ stores in the GTP response in Paramecium. External application of these inhibitors was found to dramatically alter the typical behavioral and electrophysiological responses of Paramecium to extracellular chemical stimulation. In particular, 2,5-di-tert-butylhydroquinone (BHQ) strongly inhibited the backward swimming response of paramecia to externally applied GTP, though it did not inhibit the associated whirling response. BHQ also prolonged the normally brief electro-physiological response of these cells to GTP. BHQ completely blocked the behavioral and electrophysiological responses of Paramecium to extracellular Ba2+, but had no measurable effect on the behavioral or electrophysiological responses of these cells to another depolarizing stimulus, elevated external K+ concentration. These results suggest the involvement of nonciliary Ca2+ ions in the GTP and Ba2+ responses.

References

Apr 1, 1991·The Journal of Cell Biology·N StellyA Adoutte
May 5, 1972·Science·R Eckert
Jan 27, 1995·Cell·D E Clapham
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K D ClarkD L Nelson
Jan 1, 1993·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M V WrightJ Van Houten
May 1, 1997·The Journal of Eukaryotic Microbiology·N L Elwess, J L Van Houten

❮ Previous
Next ❯

Citations

Jan 6, 2011·Basic & Clinical Pharmacology & Toxicology·Li-Ling TsengChung-Ren Jan
Mar 20, 2012·Acta Physiologica Hungarica·Chao-Chuan ChiChung-Ren Jan
Apr 12, 2008·Purinergic Signalling·Todd M Hennessey
Mar 31, 2012·Basic & Clinical Pharmacology & Toxicology·He-Hsiung ChengChung-Ren Jan
Oct 22, 2015·Biological Reviews of the Cambridge Philosophical Society·Helmut Plattner
Jun 22, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H PlattnerL Bachmann
Sep 5, 2013·The Journal of Eukaryotic Microbiology·Helmut Plattner
Apr 25, 2013·Human & Experimental Toxicology·Y-C FangC-R Jan
Aug 1, 2012·Journal of Receptor and Signal Transduction Research·Jeng-Yu TsaiChung-Ren Jan
Oct 15, 2011·Basic & Clinical Pharmacology & Toxicology·Yi-Chau LuChung-Ren Jan
Mar 17, 2011·Archives of Toxicology·Jin-Shiung ChengChung-Ren Jan
Jan 15, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wei-Chuan ChenChung-Ren Jan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.