Effect of serotonin-acting agents on the serotonin content of immune cells. A peculiar observation

Cell Biochemistry and Function
Eva Pállinger, G Csaba

Abstract

The effect of the tryptophan hydroxylase inhibitor, PCPA methylester, the serotonin reuptake inhibitor fluoxetine and MAO-A inhibitor clorgyline on the serotonin content of rat immune cells was studied, using labelled antibodies and flow cytometry. Each molecule significantly increased in males the serotonin concentration of peritoneal lymphocytes and the monocyte-macrophage-granulocyte group (mo-gran), however the agents were ineffective towards mast cells. In females fluoxetine and clorgyline increased the serotonin concentration in peritoneal lymphocytes and mo-gran. Fluoxetine also increased the serotonin level in mast cells. Thymus was absolutely resistant to the drugs in both genders. The results call attention (1) to the reverse effect of serotonin-acting agents on immune cells, (2) to the influence of the milieu where the cell is located and (3) the effect of gender.

References

Aug 18, 1989·Biochimica Et Biophysica Acta·M D BalsaM Unzeta
Mar 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I Ferjan, F Erjavec
Apr 1, 1996·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M G Livingston, H M Livingston
Jul 1, 1997·Immunology Today·A E Panerai, P Sacerdote
May 13, 1998·Immunology Today·J E Blalock
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·H LefebvreJ M Kuhn
Aug 15, 2002·Cell Biology International·G CsabaEva Pállinger
Aug 12, 2003·Trends in Immunology·John Gordon, Nicholas M Barnes
Oct 18, 2003·Biochemical Pharmacology·Diego J Walther, Michael Bader
Jan 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonio Carrillo-VicoJuan M Guerrero
Nov 25, 2004·The Journal of Clinical Endocrinology and Metabolism·Antonio Carrillo-VicoJuan M Guerrero
Jun 11, 2005·Immunology·Elizabeth J MeredithJohn Gordon

❮ Previous
Next ❯

Citations

Dec 9, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·María Emilia Di RossoAna María Genaro
Aug 25, 2009·The International Journal of Neuropsychopharmacology·Pothitos M PitychoutisZeta Papadopoulou-Daifoti
Aug 5, 2017·Frontiers in Cardiovascular Medicine·Nadine HerrDaniel Duerschmied

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.