PMID: 3749802Aug 1, 1986Paper

Effect of serotonin on bethanechol-stimulated gastric acid secretion and gastric antral motility in dogs

Scandinavian Journal of Gastroenterology
K Bech

Abstract

The purpose of the present study was to evaluate the effect of serotonin on bethanechol-stimulated gastric acid secretion and antral motility in conscious dogs with gastric fistula. Bethanechol stimulated the acid secretion dose-dependently and maintained the frequency and strength of the antral contractions at a high level. Serotonin inhibited the acid secretion dose-dependently, whereas the antral motility was stimulated. The acid inhibition was blocked by propranolol, and dose-response analysis showed inhibition of a non-competitive type. This study thereby shows that serotonin inhibits bethanechol-stimulated gastric acid secretion similarly to salmefamol (beta 2-adrenergic agonist)--that is, dose-dependently and non-competitively. Serotonin has been proposed to be a mediator of the beta-adrenergic influence on gastric function in vivo, but the counteracting effect of propranolol and the stimulatory effect of serotonin on motility contradict this hypothesis.

References

Jan 1, 1978·Scandinavian Journal of Gastroenterology·F Gottrup, J Ornsholt
Mar 1, 1975·The Journal of Physiology·C F Code, J A Marlett
Dec 1, 1985·Scandinavian Journal of Gastroenterology·K Bech, D Andersen
Jun 1, 1986·Scandinavian Journal of Gastroenterology·K Bech
Jan 1, 1981·Scandinavian Journal of Gastroenterology·F Gottrup
Jan 1, 1981·Scandinavian Journal of Gastroenterology·C P HovendalD Andersen
Jan 1, 1983·Scandinavian Journal of Gastroenterology·H MoenT Gerner

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Citations

Dec 1, 1989·Journal of Autonomic Pharmacology·K Bech
Dec 1, 1986·Scandinavian Journal of Gastroenterology·K Bech
Jan 1, 1990·Annals of the New York Academy of Sciences·R L StephensY Taché
Nov 1, 1996·Psychosomatic Medicine·H Weiner

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