Effect of serum electrolytes within normal ranges on QTc prolongation: a cross-sectional study in a Chinese rural general population

BMC Cardiovascular Disorders
Yin-Tao ChenYingxian Sun

Abstract

Many previous clinical studies have reported that prolongation of the QT interval corrected for heart rate (QTc) is associated with an increased risk of sudden cardiac death and all-cause mortality. This study aimed to explore associations between serum electrolytes and QTc prolongation in the north-eastern Chinese rural general population. We performed a cross-sectional study including 10,334 (4820 men and 5514 women) from the general population aged ≥35 years in the Liaoning Province from 2012 to 2013. Anthropometric measurements, laboratory examinations and self-reported lifestyle factor information, echocardiography and electrocardiogram were collected by trained personnel. The associations between serum electrolytes and QTc prolongation were tested using multiple linear regression and logistic regression analyses. The mean QTc interval were 415.6 ± 18.8 and 470.1 ± 23.1 ms in normal group and QTc prolongation group respectively. The prevalence of QTc prolongation increased significantly with a decrease in serum potassium and an increase in magnesium. Stepwise multiple linear regression showed that age, hypertension, waist circumference were prominently positive associated with QTc interval both in male and female populatio...Continue Reading

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Jul 3, 2020·Cardiology in the Young·Michael A FremedThomas J Starc
Aug 20, 2019·Clinical and Experimental Nephrology·Simonetta GenovesiSilvio Volmer Bertoli
Dec 22, 2020·Frontiers in Medicine·Kathleen BirdMohamed Elgendi
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Nov 17, 2020·Frontiers in Veterinary Science·Stephanie KeatingDavid J Schaeffer

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