Effect of serum nicotine level on posterior spinal fusion in an in vivo rabbit model

The Spine Journal : Official Journal of the North American Spine Society
Scott D DaffnerJohn C France

Abstract

Cigarette smoking has a deleterious effect on spinal fusion. Although some studies have implied that nicotine is primarily responsible for poor fusion outcomes, other studies suggest that nicotine may actually stimulate bone growth. Hence, there may be a dose-dependent effect of nicotine on posterior spinal fusion outcomes. The purpose of this study was to determine if such a relationship could be shown in an in vivo rabbit model. This is a prospective in vivo animal study. Twenty-four adult male New Zealand white rabbits were randomly divided into four groups. All groups received a single-level posterolateral, intertransverse process fusion at L5-L6 with autologous iliac crest bone. One group served as controls and only underwent the spine fusion surgery. Three groups received 5.25-, 10.5-, and 21-mg nicotine patches, respectively, for 5 weeks. Serum nicotine levels were recorded for each group. All animals were euthanized 5 weeks postoperatively, and spinal fusions were evaluated radiographically, by manual palpation, and biomechanically. Statistical analysis evaluated the dose response effect of outcomes variables and nicotine dosage. This study was supported by a portion of a $100,000 grant from the Orthopaedic Research and...Continue Reading

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Jul 13, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Manish K AghiJean-Valery Coumans
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Nov 10, 2020·PloS One·Laura C ShumRoman A Eliseev

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