PMID: 6983770Nov 1, 1982Paper

Effect of serum on lymphocyte blastogenesis. I. Basic characteristics of action by diseased dog serum

Veterinary Immunology and Immunopathology
O BartaP P Oyekan

Abstract

The immunoregulatory effect of serum on phytomitogen-induced lymphocyte blastogenesis was studied in 4 sera from diseased dogs and 1 serum from a clinically healthy dog. The results indicated that: (1) Each of the diseased animals responded to the given infection with a specific pattern of blastogenesis inhibition. (2) The blastogenesis suppression in vitro was proportional to the content of the suppressive serum in the medium. (3) A simultaneous presence of the mitogen and the suppressing "serum's lymphocyte immunoregulatory factors" (SLIF) was necessary for inducing blastogenesis suppression. (4) The suppressive sera most probably acted directly on the cells. (5) The final effect of the sera on lymphocyte blastogenesis was a result of an orchestrated action of blastogenesis-supporting, augmenting, and suppressing SLIF cooperating with the mitogen. (6) The suppressive pattern varied with the individual peripheral blood lymphocytes populations used in the test. (7) The blastogenesis-suppressing SLIF was heat-stable, noncytotoxic, and was not or only partially removable by absorption with peripheral blood lymphocytes. (8) The testing of SLIF activities required the use of various animal lymphocytes and a relatively complex setup...Continue Reading

References

Feb 1, 1975·The Journal of Experimental Medicine·R A Murgita, T B Tomasi
May 1, 1976·The Journal of Infectious Diseases·R J MangiF S Kantor
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S Yachnin
Nov 1, 1975·The Journal of Experimental Medicine·F V Chisari, T S Edgington
Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams
Dec 12, 1974·The New England Journal of Medicine·A H GlasgowJ A Mannick
Mar 15, 1973·Experimental Cell Research·D R Forsdyke
Jun 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·J M Mansfield, J H Wallace
Mar 1, 1983·Veterinary Immunology and Immunopathology·O Barta
Jun 1, 1981·Veterinary Immunology and Immunopathology·G A SplitterW R Usinger
Jan 1, 1981·Comparative Immunology, Microbiology and Infectious Diseases·O Barta, P P Oyekan
Oct 7, 1958·Annals of the New York Academy of Sciences·B B KAMRIN

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Citations

Mar 1, 1983·Veterinary Immunology and Immunopathology·O Barta
Jul 1, 1996·Veterinary Immunology and Immunopathology·D Schreuer, B Hammerberg
Aug 28, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·M TomanV Svobodová
Nov 5, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·T de BruinE Cox
Mar 7, 2007·Journal of the American Animal Hospital Association·Tim S RallisAlexander F Koutinas

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