May 1, 1977

Effect of sexual steroid hormones and of clomiphene on the behavioral response to L-dopa in mice

Archives Internationales De Pharmacodynamie Et De Thérapie
A Scotti de Carolis, V G Longo

Abstract

The scope of the present work was to ascertain the effects of some steroid hormones on the behavioral response of mice to L-Dopa. The drugs considered were: testosterone, mesterolone, cyproterone, estradiol, progesterone and clomiphene. The male sex steroids, having either androgen or antiandrogen properties, were able to potentiate the behavioral effect of L-Dopa in mice, while female sex steroids failed to demonstrate this activity. Clomiphene proved to be the most active in enhancing the behavioral effects of L-Dopa in mice.

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Mentioned in this Paper

Behavior, Animal
Progesterone, (9 beta,10 alpha)-Isomer
Estradiol, (16 alpha,17 beta)-Isomer
Cyproterone, 1alpha,2 alpha,9 beta,10 alpha-Isomer
Pargyline Hydrochloride
Serophene
Gonadal Steroid Hormones
Drug Interactions
Sterotate
Solvents

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